The XPD Asp312 Asn and LyS751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk

被引：41

作者：

Jiao, Li

Hassan, Manal M.

Bondy, Melissa L.

Abbruzzese, James L.

Evans, Douglas B.

Li, Donghui

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Unit 426, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[3] Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2007年 / 245卷 / 1-2期

关键词：

XPD; single nucleotide polymorphism; smoking; pancreatic cancer;

D O I：

10.1016/j.canlet.2005.12.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn 312 Asn genotype had a significantly reduced risk when compared with those carrying the (312)Asp allele (OR=0.46, 95% confidence interval 0.24-0.88) (P for interaction =0.03). The (312)ASP-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 68

页数：8

共 50 条

[1] XPD Lys751Gln and Asp312Asn polymorphisms and bladder cancer risk: a meta-analysis
Li, Chunxiang
Jiang, Zheng
Liu, Xinghan
MOLECULAR BIOLOGY REPORTS, 2010, 37 (01) : 301 - 309
[2] XPD Lys751Gln and Asp312Asn polymorphisms and bladder cancer risk: a meta-analysis
Chunxiang Li
Zheng Jiang
Xinghan Liu
Molecular Biology Reports, 2010, 37 : 301 - 309
[3] XPD Asp312Asn and Lys751Gln polymorphisms and breast cancer susceptibility: A meta-analysis
Yan, Yulan
Liang, Hongjie
Light, Morning
Li, Taijie
Deng, Yan
Li, Meng
Li, Shan
Qin, Xue
TUMOR BIOLOGY, 2014, 35 (03) : 1907 - 1915
[4] Association Between the Asp312Asn, Lys751Gln, and Arg156Arg Polymorphisms in XPD and the Risk of Prostate Cancer
Fu, Weijin
Xiao, Feifan
Zhang, Ruoheng
Li, Jiatong
Zhao, Dong
Lin, Xuandong
Xu, Yanzhen
Song, Xiaowei
Xie, Zhibin
Wen, Qiongxian
Yang, Xiaoli
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2017, 16 (06) : 692 - 704
[5] Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn and arsenic-related skin lesions
McCarty, Kathleert M.
Smith, Thomas J.
Zhou, Wei
Gonzalez, Ernesto
Quamruzzaman, Quazzi
Mahiuddin, Golam
Ryan, Louise
Su, Li
Christiani, David C.
CARCINOGENESIS, 2007, 28 (08) : 1697 - 1702
[6] Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn, and arsenic-related skin lesions
Mccarty, K.
Zhou, W.
Quamruzzaman, Q.
Rahman, M.
Mahiuddin, G.
Smith, T.
Louise, R.
Su, L.
Christiani, D.
EPIDEMIOLOGY, 2006, 17 (06) : S149 - S149
[7] Meta-analysis of two ERCC2 (XPD) polymorphisms, Asp312Asn and Lys751Gln, in breast cancer
Noel Pabalan
Ofelia Francisco-Pabalan
Lillian Sung
Hamdi Jarjanazi
Hilmi Ozcelik
Breast Cancer Research and Treatment, 2010, 124 : 531 - 541
[8] Meta-analysis of two ERCC2 (XPD) polymorphisms, Asp312Asn and Lys751Gln, in breast cancer
Pabalan, Noel
Francisco-Pabalan, Ofelia
Sung, Lillian
Jarjanazi, Hamdi
Ozcelik, Hilmi
BREAST CANCER RESEARCH AND TREATMENT, 2010, 124 (02) : 531 - 541
[9] XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer
Hansen, Rikke Dalgaard
Sorensen, Mette
Tjonneland, Anne
Overvad, Kim
Wallin, Hakan
Raaschou-Nielsen, Ole
Vogel, Ulla
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2007, 619 (1-2) : 68 - 80
[10] Association Between XPD Lys751Gln and Asp312Asn Polymorphisms and Hepatocellular Carcinoma Risk A Systematic Review And Meta-Analysis
Peng, Qiliu
Li, Shan
Lao, Xianjun
Chen, Zhiping
Li, Ruolin
Qin, Xue
MEDICINE, 2014, 93 (29) : e330

← 1 2 3 4 5 →