YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12

被引：16

作者：

Weiss, Bernard ^{[1
]}

机构：

[1] Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USA

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 05期

关键词：

D O I：

10.1128/JB.01645-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Exogenous thymine must be converted to thymidine to enable a thyA (thymidylate synthase) mutant to grow. The deoxyribose in the thymidine comes from dUMP, which must first be dephosphorylated. The nucleotidase YjjG is critical for this step. A yjjG thyA mutant cannot use thymine for growth on a glucose minimal medium.

引用

页码：2186 / 2189

页数：4

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