Biomedicine - Every joint has a silver lining

被引:12
作者
Firestein, Gary S. [1 ]
机构
[1] Univ Calif San Diego, Sch Med, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA
关键词
D O I
10.1126/science.1139574
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Therapy directed at a nonimmune cell that is unique to joints could suppress rheumatoid arthritis.
引用
收藏
页码:952 / 953
页数:2
相关论文
共 10 条
[1]   Evolving concepts of rheumatoid arthritis [J].
Firestein, GS .
NATURE, 2003, 423 (6937) :356-361
[2]   Invasive fibroblast-like synoviocytes in rheumatoid arthritis - Passive responders or transformed aggressors? [J].
Firestein, GS .
ARTHRITIS AND RHEUMATISM, 1996, 39 (11) :1781-1790
[3]   Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium [J].
Firestein, GS ;
Echeverri, F ;
Yeo, M ;
Zvaifler, NJ ;
Green, DR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10895-10900
[4]  
Franz JK, 2000, ARTHRITIS RHEUM, V43, P599, DOI 10.1002/1529-0131(200003)43:3<599::AID-ANR17>3.0.CO
[5]  
2-T
[6]   Cadherin-11 in synovial lining formation and pathology in arthritis [J].
Lee, David M. ;
Kiener, Hans P. ;
Agarwal, Sandeep K. ;
Noss, Erika H. ;
Watts, Gerald F. M. ;
Chisaka, Osamu ;
Takeichi, Masatoshi ;
Brenner, Michael B. .
SCIENCE, 2007, 315 (5814) :1006-1010
[7]   Initiation of an autoimmune response - Insights from a transgenic model of rheumatoid arthritis [J].
Mandik-Nayak, L ;
Allen, PM .
IMMUNOLOGIC RESEARCH, 2005, 32 (1-3) :5-13
[8]  
MullerLadner U, 1996, AM J PATHOL, V149, P1607
[9]   Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes [J].
Valencia, X ;
Higgins, JMG ;
Kiener, HP ;
Lee, DM ;
Podrebarac, TA ;
Dascher, CC ;
Watts, GFM ;
Mizoguchi, E ;
Simmons, B ;
Patel, DD ;
Bhan, AK ;
Brenner, MB .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (12) :1673-1679
[10]   Regional analysis of p35 mutations in rheumatoid arthritis synovium [J].
Yamanishi, Y ;
Boyle, DL ;
Rosengren, S ;
Green, DR ;
Zvaifler, NJ ;
Firestein, GS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :10025-10030