Hyposialorrhea as an early manifestation of Parkinson disease

被引：40

作者：

Cersosimo, M. G. ^{[1
]}

Tumilasci, O. R. ^{[2
]}

Raina, G. B. ^{[1
]}

Benarroch, E. E. ^{[3
]}

Cardoso, E. M. ^{[4
]}

Micheli, F. ^{[1
]}

Pazo, J. H. ^{[2
]}

机构：

[1] Univ Buenos Aires, Parkinson Dis & Movement Disorders Program, Hosp Clin Jose de San Martin, RA-1053 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Dept Neurophysiol, RA-1053 Buenos Aires, DF, Argentina

[3] Mayo Clin, Dept Neurol, Rochester, MN USA

[4] Univ Buenos Aires, Inst Invest Med A Lanari, RA-1053 Buenos Aires, DF, Argentina

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2009年 / 150卷 / 1-2期

关键词：

Parkinson disease; Hyposialorrhea; Autonomic disfunction; NERVOUS-SYSTEM; PATHOLOGY; NEURONS;

D O I：

10.1016/j.autneu.2009.04.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We sought to determine whether hyposialorrhea is an early manifestation of Parkinson disease (PD). We measured basal and citric acid stimulated secretion of whole saliva in 20 patients with early stage (Hoehn-Yahr I-II) PD who had motor symptoms for less than 1 year and were on no medication and 11 age matched controls. Compared to controls, PD patients had significant reduction of both basal (0.0964 +/- 0.08 vs 0.293 +/- 0.112 ml/min, p<0.001) and reflex (0.263 +/- 0.213 vs 0.537 +/- 0.313 ml/min, p<0.001) salivary secretion. Our findings confirm that hyposialorrhea is an early autonomic manifestation of PD. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：150 / 151

页数：2

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