Clustering for a better prediction of type 2 diabetes mellitus

被引:14
作者
Bonnefond, Amelie [1 ,2 ,3 ]
Froguel, Philippe [1 ,2 ,3 ]
机构
[1] Inst Pasteur, European Genom Inst Diabet EGID, CNRS, Inserm,UMR1283,UMR8199, Lille, France
[2] Univ Lille, CHU Lille, Lille, France
[3] Imperial Coll London, Dept Metab, London, England
基金
欧洲研究理事会;
关键词
D O I
10.1038/s41574-021-00475-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Complex phenotypic and genetic clustering of individuals who are potentially at increased risk of type 2 diabetes mellitus (T2DM) can enable the identification of individuals who are likely to develop T2DM and vascular complications. Precision medicine for prediabetes should improve prevention programmes and reduce mortality.
引用
收藏
页码:193 / 194
页数:2
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  • [1] Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
    Ahlqvist, Emma
    Storm, Petter
    Karajamaki, Annemari
    Martinell, Mats
    Dorkhan, Mozhgan
    Carlsson, Annelie
    Vikman, Petter
    Prasad, Rashmi B.
    Aly, Dina Mansour
    Almgren, Peter
    Wessman, Ylva
    Shaat, Nael
    Spegel, Peter
    Mulder, Hindrik
    Lindholm, Eero
    Melander, Olle
    Hansson, Ola
    Malmqvist, Ulf
    Lernmark, Ake
    Lahti, Kaj
    Forsen, Tom
    Tuomi, Tiinamaija
    Rosengren, Anders H.
    Groop, Leif
    [J]. LANCET DIABETES & ENDOCRINOLOGY, 2018, 6 (05) : 361 - 369
  • [3] Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know?
    Bonnefond, Amelie
    Froguel, Philippe
    [J]. CELL METABOLISM, 2015, 21 (03) : 357 - 368
  • [4] A comprehensive review of the FDA-approved labels of diabetes drugs: Indications, safety, and emerging cardiovascular safety data
    Gourgari, Evgenia
    Wilhelm, Erin E.
    Hassanzadeh, Hamid
    Aroda, Vanita R.
    Shoulson, Ira
    [J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2017, 31 (12) : 1719 - 1727
  • [5] Diabetes and aging: Epidemiologic overview
    Morley, John E.
    [J]. CLINICS IN GERIATRIC MEDICINE, 2008, 24 (03) : 395 - +
  • [6] Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Tabak, Adam G.
    Jokela, Markus
    Akbaraly, Tasnime N.
    Brunner, Eric J.
    Kivimaki, Mika
    Witte, Daniel R.
    [J]. LANCET, 2009, 373 (9682) : 2215 - 2221
  • [7] Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
    Udler, Miriam S.
    Kim, Jaegil
    von Grotthuss, Marcin
    Bonas-Guarch, Silvia
    Cole, Joanne B.
    Chiou, Joshua
    Anderson, Christopher D.
    Boehnke, Michael
    Laakso, Markku
    Atzmon, Gil
    Glaser, Benjamin
    Mercader, Josep M.
    Gaulton, Kyle
    Flannick, Jason
    Getz, Gad
    Florez, Jose C.
    [J]. PLOS MEDICINE, 2018, 15 (09)
  • [8] Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes
    Wagner, Robert
    Heni, Martin
    Tabak, Adam G.
    Machann, Juergen
    Schick, Fritz
    Randrianarisoa, Elko
    Hrabe de Angelis, Martin
    Birkenfeld, Andreas L.
    Stefan, Norbert
    Peter, Andreas
    Haering, Hans-Ulrich
    Fritsche, Andreas
    [J]. NATURE MEDICINE, 2021, 27 (01) : 49 - +