The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma

被引：21

作者：

Zhao, Shuangtao ^{[1
,2
]}

Fang, Shuangsang ^{[3
]}

Liu, Yanhua ^{[4
,5
,6
]}

Li, Xixi ^{[4
,7
]}

Liao, Shengyou ^{[3
]}

Chen, Jinwen ^{[3
]}

Liu, Jingjia ^{[3
]}

Zhao, Lianhe ^{[3
]}

Li, Hui ^{[3
]}

Zhou, Wei ^{[4
,5
,6
]}

Shen, Wenzhi ^{[4
,5
,6
]}

Dong, Xiaoli ^{[4
,5
,6
]}

Xiang, Rong ^{[4
,5
,6
]}

Wang, Luhua ^{[1
,2
]}

Zhao, Yi ^{[3
]}

机构：

[1] Peking Union Med Coll, Dept Radiat Oncol, Natl Canc Ctr, Canc Hosp, Beijing, Peoples R China

[2] Chinese Acad Med Sci, Beijing, Peoples R China

[3] Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China

[4] Nankai Univ, Sch Med, Tianjin, Peoples R China

[5] Nankai Univ, Collaborat Innovat Ctr Biotherapy, Tianjin, Peoples R China

[6] Tianjin Key Lab Tumor Microenvironm & Neurovasc R, Tianjin, Peoples R China

[7] Nankai Univ, Dept Pathol, Tianjin, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 21期

基金：

中国国家自然科学基金;

关键词：

diffuse large B-cell lymphoma; long non-coding RNA; NONHSAG026900; prognosis; biomarker; POOR-PROGNOSIS; R-CHOP; A-MYB; EXPRESSION; SURVIVAL; PROLIFERATION; MARKER; IMMUNOHISTOCHEMISTRY; RITUXIMAB; SUBTYPES;

D O I：

10.18632/oncotarget.16163

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long non-coding RNAs are known to be involved in cancer progression, but their biological functions and prognostic values are still largely unexplored in diffuse large B-cell lymphoma. In this study, long non-coding RNAs expression was characterized in 1,403 samples including normal and diffuse large B-cell lymphoma by repurposing 7 microarray datasets. Compared with any stage of normal B cells, NONHSAG026900 expression was significantly decreased in tumor samples. And in germinal center B-cell subtype, the significantly higher expression of NONHSAG026900 indicated it was a favorable prognosis biomarker. Then the prognostic power of NONHSAG026900 was validated with another independent dataset and NONHSAG026900 improved the predictive power of International Prognostic Index as an independent factor. Moreover, functional prediction and validation demonstrated that NONHSAG026900 could inhibit cell cycle activity to restrain tumor proliferation. These findings identified NONHSAG026900 as a novel prognostic biomarker and offered a new therapeutic target for diffuse large B-cell lymphoma patients.

引用

页码：34374 / 34386

页数：13

共 47 条

[1]

BARLETTA C, 1991, CANCER RES, V51, P3821

[2]

Blenk S, 2007, CANCER INFORM, V3, P399

[3] LIPCAR A Mitochondrial lnc in the Noncoding RNA Chain? [J].

Dorn, Gerald W., II .

CIRCULATION RESEARCH, 2014, 114 (10) :1548-1550

[4] Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients [J].

Feng, Shouhao ;

Lin, Shengli ;

Zou, Jidong ;

Wang, Yulong ;

Ji, Qinghai ;

Lv, Zhenghua .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2015, 2015

[5] LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia [J].

Fernando, Thilini R. ;

Rodriguez-Malave, Norma I. ;

Waters, Ella V. ;

Yan, Weihong ;

Casero, David ;

Basso, Giuseppe ;

Pigazzi, Martina ;

Rao, Dinesh S. .

MOLECULAR CANCER RESEARCH, 2015, 13 (05) :839-851

[6] Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma:: A study by the groupe d'Etude des lymphomes de l'adulte [J].

Feugier, P ;

Van Hoof, A ;

Sebban, C ;

Solal-Celigny, P ;

Bouabdallah, R ;

Fermé, C ;

Christian, B ;

Lepage, E ;

Tilly, H ;

Morschhauser, F ;

Gaulard, P ;

Salles, G ;

Bosly, A ;

Gisselbrecht, C ;

Reyes, F ;

Coiffier, B .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (18) :4117-4126

[7] Relapsed/Refractory Diffuse Large B-Cell Lymphoma [J].

Friedberg, Jonathan W. .

HEMATOLOGY-AMERICAN SOCIETY HEMATOLOGY EDUCATION PROGRAM, 2011, :498-505

[8] Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma [J].

Fu, Kai ;

Weisenburger, Dennis D. ;

Choi, William W. L. ;

Perry, Kyle D. ;

Smith, Lynette M. ;

Shi, Xinlan ;

Hans, Christine P. ;

Greiner, Timothy C. ;

Bierman, Philip J. ;

Bociek, R. Gregory ;

Armitage, James O. ;

Chan, Wing C. ;

Vose, Julie M. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (28) :4587-4594

[9] Regulation of hematopoietic cell proliferation and differentiation by the myb oncogene family of transcription factors [J].

Golay, J ;

Basilico, L ;

Loffarelli, L ;

Songia, S ;

Broccoli, V ;

Introna, M .

INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH, 1996, 26 (01) :24-32

[10]

Golay J, 1996, BLOOD, V87, P1900

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