Importance of Drug Pharmacokinetics at the Site of Action

被引:89
作者
Rizk, M. L. [1 ]
Zou, L. [2 ]
Savic, R. M. [2 ]
Dooley, K. E. [3 ]
机构
[1] Merck & Co Inc, Kenilworth, NJ 07033 USA
[2] Univ Calif San Francisco, San Francisco, CA 94143 USA
[3] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
来源
CTS-CLINICAL AND TRANSLATIONAL SCIENCE | 2017年 / 10卷 / 03期
关键词
BLOOD-BRAIN-BARRIER; PREEXPOSURE PROPHYLAXIS; TISSUE PHARMACOKINETICS; HEALTHY-VOLUNTEERS; HIV PREVENTION; BREAST-CANCER; IN-VITRO; FLUID; PENETRATION; TUMOR;
D O I
10.1111/cts.12448
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:133 / 142
页数:10
相关论文
共 108 条
[1]   Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo [J].
Abrahamsson, Annelie ;
Dabrosin, Charlotta .
ONCOTARGET, 2015, 6 (26) :22959-22969
[2]   Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men [J].
Anderson, Peter L. ;
Glidden, David V. ;
Liu, Albert ;
Buchbinder, Susan ;
Lama, Javier R. ;
Vicente Guanira, Juan ;
McMahan, Vanessa ;
Bushman, Lane R. ;
Casapia, Martin ;
Montoya-Herrera, Orlando ;
Veloso, Valdilea G. ;
Mayer, Kenneth H. ;
Chariyalertsak, Suwat ;
Schechter, Mauro ;
Bekker, Linda-Gail ;
Kallas, Esper Georges ;
Grant, Robert M. .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (151)
[3]   Management of uncomplicated urinary tract infections [J].
不详 .
WESTERN JOURNAL OF MEDICINE, 2002, 176 (01) :51-55
[4]  
[Anonymous], 2016, EMACHMP5940852015
[5]   Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis [J].
Apparaju, Sandhya Kiran ;
Gudelsky, Gary A. ;
Desai, Pankaj B. .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2008, 61 (02) :223-229
[6]   Role of Microdialysis in Pharmacokinetics and Pharmacodynamics: Current Status and Future Directions [J].
Azeredo, Francine Johansson ;
Dalla Costa, Teresa ;
Derendorf, Hartmut .
CLINICAL PHARMACOKINETICS, 2014, 53 (03) :205-212
[7]   Vascular Permeability and Drug Delivery in Cancers [J].
Azzi, Sandy ;
Hebda, Jagoda K. ;
Gavard, Julie .
FRONTIERS IN ONCOLOGY, 2013, 3
[8]   Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women [J].
Baeten, J. M. ;
Donnell, D. ;
Ndase, P. ;
Mugo, N. R. ;
Campbell, J. D. ;
Wangisi, J. ;
Tappero, J. W. ;
Bukusi, E. A. ;
Cohen, C. R. ;
Katabira, E. ;
Ronald, A. ;
Tumwesigye, E. ;
Were, E. ;
Fife, K. H. ;
Kiarie, J. ;
Farquhar, C. ;
John-Stewart, G. ;
Kakia, A. ;
Odoyo, J. ;
Mucunguzi, A. ;
Nakku-Joloba, E. ;
Twesigye, R. ;
Ngure, K. ;
Apaka, C. ;
Tamooh, H. ;
Gabona, F. ;
Mujugira, A. ;
Panteleeff, D. ;
Thomas, K. K. ;
Kidoguchi, L. ;
Krows, M. ;
Revall, J. ;
Morrison, S. ;
Haugen, H. ;
Emmanuel-Ogier, M. ;
Ondrejcek, L. ;
Coombs, R. W. ;
Frenkel, L. ;
Hendrix, C. ;
Bumpus, N. N. ;
Bangsberg, D. ;
Haberer, J. E. ;
Stevens, W. S. ;
Lingappa, J. R. ;
Celum, C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (05) :399-410
[9]   Physiologically Based Pharmacokinetic Modelling of Drug Penetration Across the Blood-Brain Barrier-Towards a Mechanistic IVIVE-Based Approach [J].
Ball, Kathryn ;
Bouzom, Francois ;
Scherrmann, Jean-Michel ;
Walther, Bernard ;
Decleves, Xavier .
AAPS JOURNAL, 2013, 15 (04) :913-932
[10]  
BANKIER RG, 1965, CAN MED ASSOC J, V93, P35