Alkaloids from the Leaves of Daphniphyllum subverticillatum

被引：26
|
作者：
Zhang, Chuan-Rui [1 ]
Liu, Hong-Bing [1 ]
Feng, Teng [1 ]
Zhu, Jian-Yong [1 ]
Geng, Mei-Yu [1 ]
Yue, Jian-Min [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 09期
关键词：
DAPHNEZOMINES;
D O I：
10.1021/np9003799
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new alkaloids, 17-hydroxydaphnigraciline (1), subdaphnidine A (2), daphnezomine L methyl ester (3), and 11-hydroxycodaphniphylline (4), along with 24 known analogues, were isolated from the leaves of Daphniphyllum subverticillatum. The structures of 1-4 were elucidated on the basis of spectroscopic methods and from chemical evidence. Daphnilongeridine (5) showed cytotoxicity against several tumor cell lines at IC50 values in the range 2.4-9.7 mu M and against the HMEC human microvascular endothelial cell line with an IC50 of 2.7 mu M.
引用
收藏
页码：1669 / 1672
页数：4
相关论文
共 50 条
  • [1] Two novel alkaloids with a unique fused hexacyclic skeleton from Daphniphyllum subverticillatum
    Yang, SP
    Yue, JM
    JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (21): : 7961 - 7966
  • [2] Further Daphniphyllum alkaloids from the leaves of Daphniphyllum macropodum MIQ
    Li, Zhen-Yu
    Chen, Ping
    Xu, Hong-Gui
    Peng, Shu-Ying
    Yang, Yi-Ming
    Zhao, Zhong-Zhen
    Guo, Yue-Wei
    HELVETICA CHIMICA ACTA, 2007, 90 (07) : 1353 - 1359
  • [3] Alkaloids from the leaves of Daphniphyllum longeracemosum
    Di, Ying-Tong
    He, Hong-Ping
    Lu, Yang
    Yi, Ping
    Li, n Li
    Wu, Li
    Hao, Xiao-Jiang
    JOURNAL OF NATURAL PRODUCTS, 2006, 69 (07): : 1074 - 1076
  • [4] Alkaloids from the Twigs and Leaves of Daphniphyllum macropodum
    Zhang, Chuan-Rui
    Liu, Hong-Bing
    Dong, Shi-Hui
    Wu, Yan
    Yue, Jian-Min
    HELVETICA CHIMICA ACTA, 2013, 96 (03) : 499 - 504
  • [5] Alkaloids from the Leaves and Stems of Daphniphyllum calycinum
    Zhan, Zha-Jun
    Rao, Gui-Wei
    Hou, Xiao-Rong
    Li, Cheng-Ping
    Shan, Wei-Guang
    HELVETICA CHIMICA ACTA, 2009, 92 (08) : 1562 - 1567
  • [6] Two New Daphniphyllum Alkaloids from the Stems and Leaves of Daphniphyllum calycinum
    Li, Zhen-Yu
    Peng, Shu-Ying
    Fang, Li
    Yang, Yi-Ming
    Guo, Yue-Wei
    CHEMISTRY & BIODIVERSITY, 2009, 6 (01) : 105 - 110
  • [7] Alkaloids from the Leaves of Daphniphyllum longeracemosum ROSENTH.
    Li, Chun-Shun
    Di, Ying-Tong
    Zhang, Qiang
    Zhang, Yu
    Tan, Chen-Jian
    Hao, Xiao-Jiang
    HELVETICA CHIMICA ACTA, 2009, 92 (04) : 653 - 659
  • [8] Further new complex daphniphyllum alkaloids from the stems and leaves of Daphniphyllum calycinum: Structure and stereochemistry
    Shen, Shou-Mao
    Li, Heng
    Wang, Jian-Rong
    Zeng, Yan-Bo
    Guo, Yue-Wei
    TETRAHEDRON, 2020, 76 (49)
  • [9] Hydroxylated Daphniphyllum Alkaloids from Daphniphyllum himalense
    Zhang, Hua
    Shyaula, Sajan L.
    Li, Jing-Ya
    Li, Jia
    Yue, Jian-Min
    JOURNAL OF NATURAL PRODUCTS, 2015, 78 (11): : 2761 - 2767
  • [10] Daphniphyllum and diterpenoid alkaloids from Daphniphyllum longeracemosum
    Li, Chun-Shun
    Di, Ying-Tong
    Mu, Shu-Zhen
    He, Hong-Ping
    Zhang, Qiang
    Fang, Xin
    Zhang, Yu
    Li, Shun-Lin
    Lu, Yang
    Gong, Yan-Qing
    Hao, Xiao-Jiang
    JOURNAL OF NATURAL PRODUCTS, 2008, 71 (07): : 1202 - 1206
12345