Fe/Cu-Mediated One-Pot Ketone Synthesis

被引：17

作者：

Kumar, Vemula Praveen ^{[1
]}

Babu, Vaddela Sudheer ^{[1
]}

Yahata, Kenzo ^{[1
]}

Kishi, Yoshito ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, 12 Oxford St, Cambridge, MA 02138 USA

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 10期

关键词：

GRIGNARD-REAGENTS; ALKYL-HALIDES; COMPLEXES; CHLORIDES; ESTERS; ROUTE; ACIDS;

D O I：

10.1021/acs.orglett.7b01128

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An Fe/Cu-mediated one-pot ketone synthesis was reported; Unlike Ni- and Pd-mediated one-pot ketone syntheses, the reported Fe/Cu-mediated method allowed selective activation and coupling of alkyl iodides over vinyl iodides. The newly developed one-pot ketone synthesis was applied to a synthesis of vinyl iodide/ketone 13, the left half of halichondrin B, as well as vinyl iodide/ketone 8a, the C20-C26 building block of halichondrins.

引用

页码：2766 / 2769

页数：4

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