Mannich-type reaction with trifluoromethylated N,O-hemiacetal:: Facile preparation of β-amino-β-trifluoromethyl carbonyl compounds

被引：71

作者：

Takaya, J ^{[1
]}

Kagoshima, H ^{[1
]}

Akiyama, T ^{[1
]}

机构：

[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 11期

关键词：

D O I：

10.1021/ol005812e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] On treatment of silyl enolates and an N,O-hemiacetal, derived from trifluoroacetaldehyde ethyl hemiacetal and p-anisidine, with GaCl3 (0.2 equiv) and C6H5COCl (0.2 equiv) in propionitrile, Mannich type reaction took place smoothly to afford beta-amino beta-trifluoromethyl carbonyl compounds in high yields.

引用

页码：1577 / 1579

页数：3

共 44 条

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