Aberrant induction of regulatory activity of CD4+CD25+ T cells by dendritic cells in HIV-infected persons with amebic liver abscess

被引:14
作者
Hsieh, Szu-Min
Chen, Mao-Yuan
Pan, Sung-Ching
Hung, Chien-Ching
Chang, Shan-Chwen
机构
[1] Natl Taiwan Univ Hosp, Dept Internal Med, Div Infect Dis, Taipei 100, Taiwan
[2] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan
关键词
amebic liver abscess; dendritic cell; cytotoxic T lymphocyte antigen 4 (CTLA4) regulatory T cells;
D O I
10.1097/01.qai.0000242457.43392.61
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To know why HIV-1-infected persons are particularly susceptible to amebic liver abscess (ALA), we investigated the role of CD4(+)CD25(+) T cells in the susceptibility of HIV-1-infected persons to this disease. Herein we show, in early stage HIV-1-infected subjects, that CD4(+) T-cell responses to Entamoeba histolytica antigen (EhAg) were selectively impaired, especially in those with ALA. EhAg-specific CD4(+) T-cell responses were normalized by depletion of CD4(+)CD25(+) cells or by addition of anti-cytotoxic T lymphocyte antigen 4 (CTLA4) antibody. Regulatory activity of CD4(+)CD25(+) T cells to suppress the EhAg-specific CD4(+) T-cell response could be induced by EhAg-primed dendritic cells (DCs) in HIN-1-infected subjects, especially in those with ALA, but not in healthy controls. Exogenous Tat-incubated DCs derived from HIV-negative subjects also could upregulate CTLA4 expression on autologous CD4(+)CD25(+) T cells and selectively suppress the EhAg-specific CD4(+) T-cell response. The results imply an interaction of the two pathogens: HIV-1, perhaps through the effect of Tat on DCs, may upregulate EhAg-specific regulatory T-cell activity to suppress T-cell response to E. histolytica, thus increasing the susceptibility to invasive amebiasis in even early-stage HIV-1-infected persons.
引用
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页码:6 / 13
页数:8
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