Feline extranodal lymphoma: response to chemotherapy and survival in 110 cats

被引:87
作者
Taylor, S. S. [1 ]
Goodfellow, M. R.
Browne, W. J.
Walding, B. [2 ]
Murphy, S. [3 ]
Tzannes, S. [4 ]
Gerou-Ferriani, M. [5 ]
Schwartz, A. [6 ]
Dobson, J. M. [7 ]
机构
[1] Univ Bristol, Div Compan Anim, Dept Vet Clin Sci, Feline Ctr, Bristol BS40 5DU, Avon, England
[2] Univ London Royal Vet Coll, Hatfield AL9 7TA, Herts, England
[3] Anim Hlth Trust, Ctr Small Anim Studies, Newmarket CB8 7UU, Suffolk, England
[4] Univ Liverpool, Dept Vet Clin Sci, Leahurst CH64 7TE, Neston, England
[5] Univ Glasgow, Fac Vet Med, Glasgow G61 1QH, Lanark, Scotland
[6] Univ Edinburgh, Easter Bush Vet Ctr, Royal Dick Sch Vet Studies, Roslin EH25 9RG, Midlothian, Scotland
[7] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England
关键词
LEUKEMIA-VIRUS; NASAL LYMPHOMA; LYMPHOSARCOMA; DOXORUBICIN; COP; CYCLOPHOSPHAMIDE; VINCRISTINE; ASSOCIATION; PROTOCOLS;
D O I
10.1111/j.1748-5827.2009.00813.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Objective To determine response to treatment, survival and prognostic factors for feline extranodal lymphoma in the UK. Methods Records of cats diagnosed with lymphoma of extranodal sites at seven referral centres were reviewed and information on signalment, tumour location, prior treatment and chemotherapy protocol recorded. Factors influencing response to treatment and survival were assessed. Results One hundred and forty-nine cases met inclusion criteria. Sixty-nine cats had nasal lymphoma, 35 renal, 15 central nervous system, 11 laryngeal and 19 miscellaneous locations. Sixty-six cats received cyclophosphamide, vincristine, prednisolone, 25 Wisconsin-Madison doxorubicin-containing multi-agent protocol, 10 prednisolone alone and nine other combinations. The response rate for the 110 treated cats was 85 center dot 5 per cent. Of cyclophosphamide, vincristine, prednisolone treated cats 72 center dot 7 per cent achieved complete remission, median survival 239 days. Sixty-four per cent of Wisconsin-Madison treated cats achieved complete remission, median survival 563 days. Cats with nasal lymphoma achieving complete remission had the longest survival (749 days) and cats with central nervous system lymphoma the shortest (70 days). If complete remission was achieved, prior treatment with corticosteroids significantly reduced survival time. Clinical Significance Cats with extranodal lymphoma respond to chemotherapy and achieve survival times comparable to other locations. Corticosteroid pretreatment reduced survival time in cats achieving complete remission.
引用
收藏
页码:584 / 592
页数:9
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