Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic Lymphohistiocytosis

被引：10

作者：

Chu, Raymond ^{[1
]}

van Eeden, Charmaine ^{[2
]}

Suresh, Sneha ^{[3
]}

Sligl, Wendy I. ^{[4
,5
]}

Osman, Mohammed ^{[2
]}

Cohen Tervaert, Jan Willem ^{[2
]}

机构：

[1] Univ Ottawa, Ottawa Hosp, Dept Med, Div Rheumatol, Ottawa, ON K1H 7W9, Canada

[2] Univ Alberta, Univ Alberta Hosp, Dept Med, Div Rheumatol, Edmonton, AB T6G 2R3, Canada

[3] Univ Alberta, Stollery Childrens Hosp, Dept Pediat, Div IHOPE, Edmonton, AB T6G 1C9, Canada

[4] Univ Alberta, Univ Alberta Hosp, Dept Crit Care Med, Edmonton, AB T6G 2B7, Canada

[5] Univ Alberta, Univ Alberta Hosp, Div Infect Dis, Dept Med, Edmonton, AB T6G 2B7, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 06期

关键词：

COVID-19; SARS-CoV-2; natural killer cells; cytokine storm; hemophagocytic lymphohistiocytosis; macrophage activation syndrome; MACROPHAGE ACTIVATION SYNDROME; JUVENILE RHEUMATOID-ARTHRITIS; KILLER-CELL DYSFUNCTION; EBOLA-VIRUS DISEASE; SOLUBLE INTERLEUKIN-2-RECEPTOR; NK CELLS; LIPOPROTEIN-LIPASE; CYTOKINE STORM; HIV-INFECTION; PERFORIN GENE;

D O I：

10.3390/ijms22062967

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in significant morbidity and mortality across the world, with no current effective treatments available. Recent studies suggest the possibility of a cytokine storm associated with severe COVID-19, similar to the biochemical profile seen in hemophagocytic lymphohistiocytosis (HLH), raising the question of possible benefits that could be derived from targeted immunosuppression in severe COVID-19 patients. We reviewed the literature regarding the diagnosis and features of HLH, particularly secondary HLH, and aimed to identify gaps in the literature to truly clarify the existence of a COVID-19 associated HLH. Diagnostic criteria such as HScore or HLH-2004 may have suboptimal performance in identifying COVID-19 HLH-like presentations, and criteria such as soluble CD163, NK cell activity, or other novel biomarkers may be more useful in identifying this entity.

引用

页码：1 / 16

页数：16

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