The enemy within: Keeping self-reactive T cells at bay in the periphery

被引：409

作者：

Walker, LSK ^{[1
]}

Abbas, AK ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 01期

关键词：

D O I：

10.1038/nri701

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The remarkable capacity of the mammalian immune system to coordinate deadly attacks against numerous invading pathogens, yet turn a blind eye to self-tissues continues to fascinate immunologists. It has been clear for some time that immune cells capable of recognizing self-proteins exist in normal individuals without seemingly causing harm. The 'peripheral tolerance' mechanisms that keep these cells in check are the focus of intense research, not least because defects in these pathways might cause autoimmune diseases. In this review, new developments in our understanding of peripheral tolerance are discussed.

引用

页码：11 / 19

页数：9

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