Statistical evaluation and comparison of comet assay results

被引：23
作者：
Ejchart, A [1 ]
Sadlej-Sosnowska, N [1 ]
机构：
[1] Inst Drug, PL-00725 Warsaw, Poland
来源：
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2003年 / 534卷 / 1-2期
关键词：
DNA damage; bleomycin; comet assay; statistics; Weibull distribution;
D O I：
10.1016/S1383-5718(02)00250-4
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A method of critical evaluation of comet assay test results is proposed. This method is based on representing frequency histograms of tail moments and %DNA in the tail with the use of the unsymmetrical Weibull distribution. The distribution is fully characterized by two parameters: shape (a) and scale (). Coefficients of variation and confidence intervals of the parameters have been determined. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：85 / 92
页数：8
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