Current insights into the mechanism of mammalian immunoglobulin class switch recombination

被引：76

作者：

Yu, Kefei ^{[1
]}

Lieber, Michael R. ^{[2
,3
,4
,5
]}

机构：

[1] Michigan State Univ, Dept Microbiol & Mol Genet, Biomed Phys Sci, E Lansing, MI 48824 USA

[2] USC Norris Comprehens Canc Ctr, Dept Pathol, Los Angeles, CA 90033 USA

[3] USC Norris Comprehens Canc Ctr, Dept Mol Microbiol & Immunol, Los Angeles, CA USA

[4] USC Norris Comprehens Canc Ctr, Dept Biochem & Mol Biol, Los Angeles, CA USA

[5] USC Norris Comprehens Canc Ctr, Dept Biol Sci, Sect Mol & Computat Biol, Los Angeles, CA USA

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2019年 / 54卷 / 04期

关键词：

R-loop; DNA repair; DNA recombination; immunoglobulin gene rearrangement; isotype switching; activation-induced deaminase; RNase H; INDUCED CYTIDINE DEAMINASE; SINGLE-STRANDED-DNA; R-LOOP FORMATION; RNA-POLYMERASE-II; SOMATIC HYPERMUTATION; REGION RECOMBINATION; MOLECULAR-MECHANISMS; RNA/DNA HYBRIDS; MISMATCH REPAIR; G-DENSITY;

D O I：

10.1080/10409238.2019.1659227

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunoglobulin (Ig) class switch recombination (CSR) is the gene rearrangement process by which B lymphocytes change the Ig heavy chain constant region to permit a switch of Ig isotype from IgM to IgG, IgA, or IgE. At the DNA level, CSR occurs via generation and joining of DNA double strand breaks (DSBs) at intronic switch regions located just upstream of each of the heavy chain constant regions. Activation-induced deaminase (AID), a B cell specific enzyme, catalyzes cytosine deaminations (converting cytosines to uracils) as the initial DNA lesions that eventually lead to DSBs and CSR. Progress on AID structure integrates very well with knowledge about Ig class switch region nucleic acid structures that are supported by functional studies. It is an ideal time to review what is known about the mechanism of Ig CSR and its relation to somatic hypermutation. There have been many comprehensive reviews on various aspects of the CSR reaction and regulation of AID expression and activity. This review is focused on the relation between AID and switch region nucleic acid structures, with a particular emphasis on R-loops.

引用

页码：333 / 351

页数：19

共 157 条

[1] Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination [J].

Al Ismail, Azza ;

Husain, Afzal ;

Kobayashi, Maki ;

Honjo, Tasuku ;

Begum, Nasim A. .

INTERNATIONAL IMMUNOLOGY, 2017, 29 (11) :525-537

[2] Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence [J].

Balk, Bettina ;

Maicher, Andre ;

Dees, Martina ;

Klermund, Julia ;

Luke-Glaser, Sarah ;

Bender, Katharina ;

Luke, Brian .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 20 (10) :1199-+

[3] Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations [J].

Balter, Barbara B. ;

Ciccone, David N. ;

Oettinger, Marjorie A. ;

Selsing, Erik .

MOLECULAR IMMUNOLOGY, 2012, 52 (01) :1-8

[4] C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion [J].

Barreto, V ;

Reina-San-Martin, B ;

Ramiro, AR ;

McBride, KM ;

Nussenzweig, MC .

MOLECULAR CELL, 2003, 12 (02) :501-508

[5] The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates [J].

Basu, Uttiya ;

Meng, Fei-Long ;

Keim, Celia ;

Grinstein, Veronika ;

Pefanis, Evangelos ;

Eccleston, Jennifer ;

Zhang, Tingting ;

Myers, Darienne ;

Wasserman, Caitlyn R. ;

Wesemann, Duane R. ;

Januszyk, Kurt ;

Gregory, Richard I. ;

Deng, Haiteng ;

Lima, Christopher D. ;

Alt, Frederick W. .

CELL, 2011, 144 (03) :353-363

[6]

Biffi G, 2014, NAT CHEM, V6, P75, DOI [10.1038/nchem.1805, 10.1038/NCHEM.1805]

[7]

Biffi G, 2013, NAT CHEM, V5, P182, DOI [10.1038/NCHEM.1548, 10.1038/nchem.1548]

[8] DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells [J].

Bjorkman, Andrea ;

Du, Likun ;

Felgentreff, Kerstin ;

Rosner, Cornelia ;

Kamdar, Radhika Pankaj ;

Kokaraki, Georgia ;

Matsumoto, Yoshihisa ;

Davies, E. Graham ;

van der Burg, Mirjam ;

Notarangelo, Luigi D. ;

Hammarstrom, Lennart ;

Pan-Hammarstrom, Qiang .

JOURNAL OF IMMUNOLOGY, 2015, 195 (12) :5608-5615

[9] DNA-dependent protein kinase activity is not required for immunoglobulin class switching [J].

Bosma, GC ;

Kim, J ;

Urich, T ;

Fath, DM ;

Cotticelli, MG ;

Ruetsch, NR ;

Radic, MZ ;

Bosma, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (11) :1483-1495

[10] S-REGION TRANSCRIPTION PER-SE PROMOTES BASAL IGE CLASS SWITCH RECOMBINATION BUT ADDITIONAL FACTORS REGULATE THE EFFICIENCY OF THE PROCESS [J].

BOTTARO, A ;

LANSFORD, R ;

XU, LX ;

ZHANG, J ;

ROTHMAN, P ;

ALT, FW .

EMBO JOURNAL, 1994, 13 (03) :665-674

← 1 2 3 4 5 6 7 8 9 10 →