Prognostic value of long non-coding RNA MALAT1 in cancer patients

被引：27

作者：

Wu, Yihua ^{[1
,2
]}

Lu, Wei ^{[1
]}

Xu, Jinming ^{[1
]}

Shi, Yu ^{[3
]}

Zhang, Honghe ^{[4
]}

Xia, Dajing ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Publ Hlth, Dept Toxicol, 866 Yuhangtang Rd, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth, 866 Yuhangtang Rd, Hangzhou 310003, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, 866 Yuhangtang Rd, Hangzhou 310003, Zhejiang, Peoples R China

[4] Zhejiang Univ, Sch Med, Dept Pathol, 866 Yuhangtang Rd, Hangzhou 310003, Zhejiang, Peoples R China

来源：

TUMOR BIOLOGY | 2016年 / 37卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1); Cancer; Prognostic value; POOR-PROGNOSIS; GASTRIC-CANCER; LNCRNA MALAT1; LUNG-CANCER; METASTASIS; PROMOTES; EXPRESSION; MIGRATION; PROLIFERATION; BIOMARKER;

D O I：

10.1007/s13277-015-3870-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) was identified to be the first long non-coding RNA as a biomarker of independent prognostic value for early stage non-small cell lung cancer patient survival. In recent years, the association between upregulated tissue MALAT1 level and incidence of various cancers including bladder cancer, colorectal cancer, and renal cancer has been widely discussed. The aim of our present study was to assess the potential prognostic value of MALAT1 in various human cancers. PubMed, Embase, Ovid, and Cochrane Library databases were systematically searched, and eligible studies evaluating the prognostic value of MALAT1 in various cancers were included. Finally, 11 studies encompassing 1216 participants reporting with sufficient data were enrolled in the current meta-analysis. The pooled hazard ratio (HR) was 2.05 (95 % confidence interval (CI) 1.64-2.55, p < 0.01) for overall survival (OS) and 2.66 (95 % CI 1.86-3.80, p < 0.01) for disease-free survival (DFS). In conclusion, high tissue MALAT1 level was associated with an inferior clinical outcome in various cancers, suggesting that MALAT1 might serve as a potential prognostic biomarker for various cancers.

引用

页码：897 / 903

页数：7

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