Simple synthesis of 1-substituted-4-vinyl-1,2,3-triazoles based on polystyrene-supported sulfonyl chloride

被引：5
|
作者：
Wang, Zhe [1 ,2 ]
Sheng, Shou-Ri [1 ,2 ]
Wei, Mei-Hong [1 ]
Liu, Xiao-Ling [1 ]
机构：
[1] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Peoples R China
[2] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Click chemistry; elimination reaction; solid-phase organic synthesis; polystyrene-supported but-3-ynyl sulfonate; 4-vinyl-1,2,3-triazoles; CLICK CHEMISTRY; TERMINAL ALKYNES; MONOMER FAMILY; SOLID-PHASE; CYCLOADDITION; 1,2,3-TRIAZOLES; AZIDES; VINYLTRIAZOLES;
D O I：
10.1080/00397911.2015.1130228
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polystyrene-supported but-3-ynyl sulfonate reagent has been developed and applied to the traceless solid-phase organic synthesis of 1-substituted-4-vinyl-1,2,3-triazoles by CuI-promoted 1,3-dipolar cycloaddition reaction with various organic azides and subsequent cleavage from the polymer support through elimination reaction mediated by 1.8-diazabicyclo[5,4,0]undec-7-ene (DBU). The advantages of this new synthetic method include simple operation and moderate to good yields of the products, as well as good stability of the reagent.
引用
收藏
页码：226 / 231
页数：6
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