Varicella zoster immunity loss in multiple sclerosis patient treated with ocrelizumab

被引：6
作者：
Rapisarda, L. [1 ]
Valentino, P. [1 ]
Barone, S. [1 ]
Torti, C. [2 ]
La Gamba, V. [2 ]
Fortunato, F. [1 ]
Sammarra, I. [1 ]
Gambardella, A. [1 ]
机构：
[1] Magna Graecia Univ Catanzaro, Inst Neurol, Dept Med & Surg Sci, Catanzaro, Italy
[2] Magna Graecia Univ Catanzaro, Infect & Trop Dis Unit, Dept Med & Surg Sci, Catanzaro, Italy
来源：
CLINICAL IMMUNOLOGY | 2021年 / 223卷
关键词：
Varicella zoster; Ocrelizumab; Multiple sclerosis; Immunity;
D O I：
10.1016/j.clim.2020.108554
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ocrelizumab is a novel humanized anti-CD20 antibody used for treatment of relapsing remitting and primary progressive multiple sclerosis with evidence of inflammatory activity. Guidelines suggest assessing vaccination status and eventually vaccinate patients with multiple sclerosis before new disease modifying therapy initiation. However, there are not any specific recommendations about vaccinal immunity reassessment after ocrelizumab injection. We describe the case of a patient who loss varicella zoster vaccinal immunity after the first ocrelizumab infusion. It is advisable to reassess vaccinal immunity to isolate non-immune patients and to adopt suitable preventive measures, including close contacts vaccination and avoidance of contacts with active infection.
引用
收藏
页数：3
相关论文
共 8 条
  • [1] Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis The VELOCE study
    Bar-Or, Amit
    Calkwood, Jonathan C.
    Chognot, Cathy
    Evershed, Joanna
    Fox, Edward J.
    Herman, Ann
    Manfrini, Marianna
    McNamara, John
    Robertson, Derrick S.
    Stokmaier, Daniela
    Wendt, Jeanette K.
    Winthrop, Kevin L.
    Traboulsee, Anthony
    [J]. NEUROLOGY, 2020, 95 (14) : E1999 - E2008
  • [2] PREVENTION OF VARICELLA BY ZOSTER IMMUNE GLOBULIN
    BRUNELL, PA
    ROSS, A
    MILLER, LH
    KUO, B
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1969, 280 (22) : 1191 - &
  • [3] Practice guideline update summary: Vaccine-preventable infections and immunization in multiple sclerosis Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
    Farez, Mauricio F.
    Correale, Jorge
    Armstrong, Melissa J.
    Rae-Grant, Alexander
    Gloss, David
    Donley, Diane
    Holler-Managan, Yolanda
    Kachuck, Norman J.
    Jeffery, Douglas
    Beilman, Maureen
    Gronseth, Gary
    Michelson, David
    Lee, Erin
    Cox, Julie
    Getchius, Tom
    Sejvar, James
    Narayanaswami, Pushpa
    [J]. NEUROLOGY, 2019, 93 (13) : 584 - 594
  • [4] Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis
    Hauser, S. L.
    Bar-Or, A.
    Comi, G.
    Giovannoni, G.
    Hartung, H. -P.
    Hemmer, B.
    Lublin, F.
    Montalban, X.
    Rammohan, K. W.
    Selmaj, K.
    Traboulsee, A.
    Wolinsky, J. S.
    Arnold, D. L.
    Klingelschmitt, G.
    Masterman, D.
    Fontoura, P.
    Belachew, S.
    Chin, P.
    Mairon, N.
    Garren, H.
    Kappos, L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (03) : 221 - 234
  • [5] Immunization and multiple sclerosis: Recommendations from the French multiple sclerosis society
    Lebrun, Christine
    Vukusic, Sandra
    Lebrun-frenay, Christine
    De Seze, Jerome
    Ayrignac, Xavier
    Bensa, Caroline
    Le Page, Emmanuelle
    Ouallet, Jean-Christophe
    Thouvenot, Eric
    Zephir, Helene
    Bourre, Bertrand
    Casez, Olivier
    Ciron, Jonathan
    Cohen, Mikael
    Collongues, Nicolas
    Davenas, Charlotte
    Derache, Nathalie
    Guennoc, Anne Marie
    Hadhoum, Nawal
    Louapre, Celine
    Maarouf, Adil
    Mathey, Guillaume
    Michel, Laure
    Maillart, Elisabeth
    Pittion, Sophie
    Ruet, Aurelie
    Wiertlewski, Sandrine
    Audoin, Bertrand
    Berger, Eric
    Bernady, Patricia
    Brassat, David
    Brochet, Bruno
    Cabre, Philippe
    Camdessanche, Jean Philippe
    Coustans, Marc
    Debouverie, Marc
    Edan, Gilles
    Elias, Zyiad
    Faucheux, Jean Marc
    Gout, Olivier
    Hautecoeur, Patrick
    Heinzlef, Olivier
    Labauge, Pierre
    Laplaud, David
    Leray, Emmanuelle
    Magy, Laurent
    Mekies, Claude
    Merienne, Marc
    Moreau, Thibaut
    Papeix, Caroline
    [J]. MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2019, 31 : 173 - 188
  • [6] Vaccinations in adults with chronic inflammatory joint disease: Immunization schedule and recommendations for patients taking synthetic or biological disease-modifying antirheumatic drugs
    Morel, Jacques
    Czitrom, Severine Guillaume
    Mallick, Auriane
    Sellam, Jeremie
    Sibilia, Jean
    [J]. JOINT BONE SPINE, 2016, 83 (02) : 135 - 141
  • [7] Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine
    Patterson-Bartlett, Julie
    Levin, Myron J.
    Lang, Nancy
    Schodel, Florian P.
    Vessey, Rupert
    Weinberg, Adriana
    [J]. VACCINE, 2007, 25 (41) : 7087 - 7093
  • [8] Diabetes as a risk factor for herpes zoster in adults: A synthetic literature review
    Saadatian-Elahi, Mitra
    Bauduceau, Bernard
    Del-Signore, Corinne
    Vanhems, Philippe
    [J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2020, 159
1