NIR imaging-guided combined photodynamic therapy and chemotherapy by a pH-responsive amphiphilic polypeptide prodrug

被引：44
作者：
Ruan, Zheng [1 ,2 ]
Liu, Le [1 ,2 ]
Jiang, Wei [3 ]
Li, Shuya [3 ]
Wang, Yucai [3 ]
Yan, Lifeng [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Key Lab Soft Matter Chem, Hefei Natl Lab Phys Sci Microscale, iChEM, Jinzai Rd 96, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem Phys, Jinzai Rd 96, Hefei 230026, Anhui, Peoples R China
[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
来源：
BIOMATERIALS SCIENCE | 2017年 / 5卷 / 02期
基金：
中国国家自然科学基金;
关键词：
INFRARED FLUORESCENCE PROBE; TARGETED SIRNA DELIVERY; DRUG-DELIVERY; BODIPY DYES; N-CARBOXYANHYDRIDES; POLYMERIC MICELLES; TRIGGERED RELEASE; TUMOR; DOXORUBICIN; CHEMISTRY;
D O I：
10.1039/c6bm00787b
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
pH-Sensitive doxorubicin conjugated polymeric micelles entrapped with near infrared (NIR) photosensitizer BODIPY (which works as an imaging agent at the same time) were designed and synthesized by ring opening polymerization of N-carboxyanhydride with mPEG-NH2 as the initiator, following reaction with doxorubicin to form the hydrazone-bond linker for pH responsiveness. Then the NIR dye (BODIPY) was loaded in the micelles for both bioimaging and photodynamic therapy (PDT). A significant cytotoxicity of NIR imaging-guided combined PDT and chemotherapy could be found by MTT assays, which was also confirmed with a fluorescence microscope, indicating a new kind of polymeric nanoparticle for potential theranostic treatment of cancers. In addition, the energy density of the laser for the PDT is extremely low.
引用
收藏
页码：313 / 321
页数：9
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