Qualitative analysis of designer drugs by paper spray ionisation mass spectrometry (PSI-MS)

被引:39
作者
Carvalho, Thays C. [1 ]
Oliveira, Izabela F. [2 ,3 ]
Tose, Lilian V. [2 ]
Vanini, Gabriela [2 ]
Kill, Jade B. [2 ]
Neto, Alvaro C. [2 ]
Machado, Leandro F. [4 ]
Ambrosio, Joao C. L. [4 ]
Lacerda, Valdemar, Jr. [2 ]
Vaz, Boniek G. [1 ]
Romao, Wanderson [2 ,3 ]
机构
[1] Univ Fed Goias, Chem Inst, BR-74001970 Goiania, Go, Brazil
[2] Univ Fed Espirito Santo, Dept Chem, Petrole & Forens Lab, BR-29075910 Vitoria, ES, Brazil
[3] Fed Inst Educ Sci & Technol Espirito Santo, BR-29106010 Vila Velha, ES, Brazil
[4] Natl Inst Criminalist, Minist Justice, Fed Brazilian Police, BR-70610200 Brasilia, DF, Brazil
关键词
LEGAL HIGHS; IDENTIFICATION; SAMPLES; LSD;
D O I
10.1039/c5ay01265a
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The application of ambient ionization mass spectrometry such as paper spray ionisation (PSI) is a fast, powerful, and simple method to analyze designer drugs directly on the surface of blotters. PSI-MS does not require nebulizing gas and heating temperature as well as complex protocols for sample preparation. Herein, it was possible to identify and elucidate the chemical structure of designer drugs using tandem mass spectrometry experiments from a triangular blotter. Substances such as lysergic acid diethylamide (LSD), and five new designer drugs (2,5-dimethoxy-4-chloroamphetamine (DOC), 2,5-dimethoxy-4-bromoamphetamine (DOB), 25C-NBOMe, 25B-NBOMe, and 25I-NBOMe) were characterized by PSI-MS. The PSI(+)-MS and PSI(+)-MS/MS data confirmed the assignments of the designer drugs and fragmentation mechanisms have been proposed. From losses of 17 Da (NH3), which is typical of primary amines, the CID results suggest the presence of isomers in the chemical composition of the NBOMe class. Additionally, the data were compared to those of ultra-high-resolution mass spectroscopy (positive-ion electrospray ionization coupled with Fourier transform ion cyclotron mass spectrometry, ESI(+)FT-ICR MS).
引用
收藏
页码:614 / 620
页数:7
相关论文
共 30 条
[1]  
[Anonymous], 2012, EU DRUGS MARKETS REP
[2]   Analyses of second-generation 'legal highs' in the UK: Initial findings [J].
Brandt, Simon D. ;
Sumnall, Harry R. ;
Measham, Fiona ;
Cole, Jon .
DRUG TESTING AND ANALYSIS, 2010, 2 (7-8) :377-382
[3]   Elucidation of LSD in vitro metabolism by liquid chromatography and capillary electrophoresis coupled with tandem mass spectrometry [J].
Cai, JY ;
Henion, J .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1996, 20 (01) :27-37
[4]   Rapid analysis of whole blood by paper spray mass spectrometry for point-of-care therapeutic drug monitoring [J].
Espy, Ryan D. ;
Manicke, Nicholas E. ;
Ouyang, Zheng ;
Cooks, R. Graham .
ANALYST, 2012, 137 (10) :2344-2349
[5]   Electrospray Ionization Using Wooden Tips [J].
Hu, Bin ;
So, Pui-Kin ;
Chen, Huanwen ;
Yao, Zhong-Ping .
ANALYTICAL CHEMISTRY, 2011, 83 (21) :8201-8207
[6]   Leaf Spray: Direct Chemical Analysis of Plant Material and Living Plants by Mass Spectrometry [J].
Liu, Jiangjiang ;
Wang, He ;
Cooks, R. Graham ;
Ouyang, Zheng .
ANALYTICAL CHEMISTRY, 2011, 83 (20) :7608-7613
[7]   Development, Characterization, and Application of Paper Spray Ionization [J].
Liu, Jiangjiang ;
Wang, He ;
Manicke, Nicholas E. ;
Lin, Jin-Ming ;
Cooks, R. Graham ;
Ouyang, Zheng .
ANALYTICAL CHEMISTRY, 2010, 82 (06) :2463-2471
[8]   Rapid analysis of synthetic cannabinoids using a miniature mass spectrometer with ambient ionization capability [J].
Ma, Qiang ;
Bai, Hua ;
Li, Wentao ;
Wang, Chao ;
Cooks, R. Graham ;
Ouyang, Zheng .
TALANTA, 2015, 142 :190-196
[9]   Assessment of paper spray ionization for quantitation of pharmaceuticals in blood spots [J].
Manicke, Nicholas E. ;
Yang, Qian ;
Wang, He ;
Oradu, Sheran ;
Ouyang, Zheng ;
Cooks, R. Graham .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2011, 300 (2-3) :123-129
[10]   Chemical identification of cannabinoids in street marijuana samples using electrospray ionization FT-ICR mass spectrometry [J].
Nascimento, Iendel R. ;
Costa, Helber B. ;
Souza, Lindamara M. ;
Soprani, Leticia C. ;
Merlo, Bianca B. ;
Romao, Wanderson .
ANALYTICAL METHODS, 2015, 7 (04) :1415-1424