Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P1) receptor agonists

被引：8

作者：

Zecri, Frederic J. ^{[1
]}

Albert, Rainer

Landrum, Gregory ^{[1
]}

Hinterding, Klaus ^{[2
]}

Cooke, Nigel G. ^{[1
]}

Guerini, Danilo ^{[1
]}

Streiff, Markus ^{[1
]}

Bruns, Christian ^{[1
]}

Nuesslein-Hildesheim, Barbara ^{[1
]}

机构：

[1] Novartis Inst BioMed Res, CH-4056 Basel, Switzerland

[2] F Hoffmann La Roche Ltd, CH-4070 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 01期

关键词：

S1P(1) agonist; Carene; Pharmacophore model; LIGAND-BINDING POCKET; SPHINGOSINE; 1-PHOSPHATE; 3-ARYLPROPIONIC ACIDS; LYMPHOCYTE EGRESS; IDENTIFICATION; MODULATORS; DISCOVERY; AFFINITY; SUBTYPES; FTY720;

D O I：

10.1016/j.bmcl.2009.11.045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

High throughput screening and hit to lead optimization led to the identification of 'carene' as a promising scaffold showing selective S1P(1) receptor agonism. In parallel to this work we have established a pharmacophore model for the S1P(1) receptor highlighting the minimal structural requirement necessary for potent receptor agonism. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：35 / 37

页数：3

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