Synthesis of new Targretin® analogues that induce apoptosis in leukemia HL-60 cells

被引：7
作者：
Winum, JY
Baghdiguian, S
Commes, T
Leydet, A
Montero, JL
机构：
[1] Univ Montpellier 2, Lab Chim Biomol, UMR 5032, CNRS,Lab Mayoly Spindler,ENSCM, F-34296 Montpellier, France
[2] Univ Montpellier 2, Lab Dynam Mol Interact Membranaires, UMR 5539, CNRS, F-34095 Montpellier, France
[3] CNRS, Inst Genet Humaine, UPR 1142, F-34396 Montpellier, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 24期
关键词：
D O I：
10.1016/S0960-894X(02)00803-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new analogues of Targretin where the carboxylic acid function was replaced by an N,N-dimethyl-S-aryl carbamate or N,N-dimethyl-O-arylthiocarbamate function, were synthesized. Compounds 5, 6 and 7 have shown to be more potent than the parent compound to induce apoptosis of HL-60 cells. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3529 / 3532
页数：4
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