Novel insights into plasma biomarker candidates in patients with chronic mountain sickness based on proteomics

被引：16

作者：

Zhang, Peili ^{[1
,2
,3
]}

Li, Zhanquan ^{[1
,2
,4
]}

Yang, Faman ^{[4
]}

Ji, Linhua ^{[1
,2
,5
]}

Yang, Yingzhong ^{[1
,2
]}

Liu, Chuanchuan ^{[1
,2
]}

Liu, Huihui ^{[1
,2
]}

Ma, Jie ^{[4
]}

Liu, Jie ^{[1
,2
]}

Dang, Zhancui ^{[1
,2
]}

Wang, Shengyan ^{[1
,2
]}

Ge, Rili ^{[1
,2
]}

Cui, Sen ^{[4
]}

机构：

[1] Qinghai Univ, Res Ctr High Altitude Med, Xining, Peoples R China

[2] Key Lab Applicat & Fdn High Altitude Med Res Qing, Xining, Peoples R China

[3] Southern Med Univ, Huadu Dist Peoples Hosp, Dept Gen Practice, Guangzhou, Peoples R China

[4] Qinghai Univ, Affiliated Hosp, Dept Hematol, Xining, Peoples R China

[5] Southern Med Univ, Huadu Dist Peoples Hosp, Dept Hematol, Guangzhou, Peoples R China

来源：

BIOSCIENCE REPORTS | 2021年 / 41卷 / 01期

关键词：

HIGH-ALTITUDE; EXCESSIVE ERYTHROCYTOSIS; HEMOGLOBIN; HAPTOGLOBIN; PREVALENCE; EXPOSURE; HYPOXIA; PROTEIN; IRON;

D O I：

10.1042/BSR20202219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by lifelong exposure to hypoxia. In the present study, proteomic analysis was used to identify the differentially expressed proteins (DEPs) and then evaluate the potential plasma biomarkers between CMS and non-CMS groups. A total of 145 DEPs were detected in CMS Han Chinese people who live in the plateau (CMS-HPu), among which 89 were significantly up-regulated and 56 were significantly down-regulated. GO enrichment analysis showed that various biological processes were enriched, including the hydrogen peroxide metabolic/catabolic process, reactive oxygen species (ROS) metabolic, and acute inflammatory response. Protein-protein interaction analysis showed that antioxidant activity, the hydrogen peroxide catabolic process and peroxidase activity were primarily mapped in interaction proteins. Nine modules showed significantly clustering based on WGCNA analysis, with two being the most significant, and GO analysis showed that proteins of both modules were primarily enriched in oxidative stress-related biological processes. Four DEPs increased in CMS patients were evaluated as the candidate biomarkers, and three showed significant AUC: hemoglobin beta chain (HB-beta), thioredoxin-1 (TRX1), and phosphoglycerate kinase 1 (PGK1). The present study provides insights into the pathogenesis of CMS and further evaluates the potentially biomarkers for its prevention and treatment of it.

引用

页数：15

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