The Helicobacter pylori Mfd protein is important for antibiotic resistance and DNA repair

被引：17
|
作者：
Lee, Gin Hyug [1 ]
Jeong, Jin-Yong [2 ]
Chung, Jun-Won [1 ]
Nam, Won-Hee [2 ]
Lee, Sun-Mi [2 ]
Pak, Jhang-Ho [2 ]
Choi, Kee Don [1 ]
Song, Ho June [1 ]
Jung, Hwoon-Yong [1 ]
Kim, Jin-Ho [1 ]
机构：
[1] Univ Ulsan, Asan Med Ctr, Div Gastroenterol, Dept Internal Med,Coll Med, Seoul 138736, South Korea
[2] Univ Ulsan, Asan Med Ctr, Asan Inst Life Sci, Coll Med, Seoul 138736, South Korea
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2009年 / 65卷 / 04期
关键词：
Helicobacter pylori; Antibiotic resistance; DNA repair; EXCISION; MUTANT;
D O I：
10.1016/j.diagmicrobio.2009.08.007
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A Helicobacter pylori mutant defective in a putative mfd gene was constructed and characterized. The mfd gene is required for DNA repair and is involved in DNA recombination processes. The mfd mutant strain displayed a greatly increased susceptibility to antibiotics, indicating that this gene plays a significant role in the antibiotic resistance of H. pylori strain J99. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：454 / 456
页数：3
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