The Helicobacter pylori Mfd protein is important for antibiotic resistance and DNA repair

被引：17

作者：

Lee, Gin Hyug ^{[1
]}

Jeong, Jin-Yong ^{[2
]}

Chung, Jun-Won ^{[1
]}

Nam, Won-Hee ^{[2
]}

Lee, Sun-Mi ^{[2
]}

Pak, Jhang-Ho ^{[2
]}

Choi, Kee Don ^{[1
]}

Song, Ho June ^{[1
]}

Jung, Hwoon-Yong ^{[1
]}

Kim, Jin-Ho ^{[1
]}

机构：

[1] Univ Ulsan, Asan Med Ctr, Div Gastroenterol, Dept Internal Med,Coll Med, Seoul 138736, South Korea

[2] Univ Ulsan, Asan Med Ctr, Asan Inst Life Sci, Coll Med, Seoul 138736, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2009年 / 65卷 / 04期

关键词：

Helicobacter pylori; Antibiotic resistance; DNA repair; EXCISION; MUTANT;

D O I：

10.1016/j.diagmicrobio.2009.08.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A Helicobacter pylori mutant defective in a putative mfd gene was constructed and characterized. The mfd gene is required for DNA repair and is involved in DNA recombination processes. The mfd mutant strain displayed a greatly increased susceptibility to antibiotics, indicating that this gene plays a significant role in the antibiotic resistance of H. pylori strain J99. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：454 / 456

页数：3

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