Mitochondrial composition and function under the control of hypoxia

被引：470

作者：

Fuhrmann, Dominik C. ^{[1
]}

Bruene, Bernhard ^{[1
,2
]}

机构：

[1] Goethe Univ Frankfurt, Inst Biochem 1, Fac Med, 1 Theodor Stern Kai, D-60590 Frankfurt, Germany

[2] Fraunhofer Inst Mol Biol & Appl Ecol, Project Grp Translat Med & Pharmacol TMP, D-60596 Frankfurt, Germany

来源：

REDOX BIOLOGY | 2017年 / 12卷

关键词：

Mitochondria; ROS; Hypoxia; HIF; Respiratory chain; RESPIRATORY COMPLEX-I; ELECTRON-TRANSPORT CHAIN; PROLYL-HYDROXYLASES; INDUCIBLE FACTOR; OXIDATIVE-PHOSPHORYLATION; HEPATOCELLULAR-CARCINOMA; REPERFUSION INJURY; REDOX HOMEOSTASIS; INDUCED AUTOPHAGY; INDUCED MIGRATION;

D O I：

10.1016/j.redox.2017.02.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS). In response to hypoxia they exchange or modify distinct subunits of the respiratory chain and adjust their metabolism, especially lowering the citric acid cycle. Intermediates of the citric acid cycle participate in regulating hypoxia inducible factors (HIF), the key mediators of adaptation to hypoxia. Here we summarize how hypoxia conditions mitochondria with consequences for ROS-production and the HIF-pathway.

引用

页码：208 / 215

页数：8

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