Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study

被引:60
作者
Hunt, KJ
Duggirala, R
Göring, HHH
Williams, JT
Almasy, L
Blangero, J
O'Leary, DH
Stern, MP
机构
[1] Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Epidemiol, San Antonio, TX 78229 USA
[2] SW Fdn Biomed Res, Dept Genet, San Antonio, TX USA
[3] Tufts New England Med Ctr, Dept Radiol, Boston, MA USA
关键词
epidemiology; genetics; risk factors;
D O I
10.1161/01.STR.0000043827.03966.EF
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-In contrast to the commonly used quantitative marker of subclinical atherosclerosis, namely intima-media thickness, we investigated the extent to which the presence or absence of carotid artery plaque (CAP) was under genetic control. Methods-The study population consisted of 750 individuals distributed across 29 randomly ascertained extended Mexican American pedigrees who participated in the second examination cycle of the San Antonio Family Heart Study. Extracranial focal CAP was identified by B-mode ultrasound bilaterally in the internal carotid artery or the carotid bulb. Using a variance decomposition approach implemented in the SOLAR computer program, we performed genetic analysis on the discrete trait CAP (ie, liability to disease) using a threshold model. Covariates considered in the analysis included age, sex, diabetes, current smoking status, lipid levels, and markers of hypertension and obesity. Results-Fifty-one of 461 women and fifty-seven of 289 men with a mean age of 42.1 years had evidence of a plaque in the right and/or left carotid artery. The age- and sex-adjusted heritability (h(2)+/-SE) for CAP was significant (h(2)=0.28+/-0.15, P=0.01). Furthermore, after adjustment for additional covariates that contributed significantly to the model (P<0.05; diabetes, hypertension, body mass index, waist circumference, and smoking status), heritability remained significant (h(2)=0.23+/-0.15, P=0.03). Conclusions-Our data indicate that after established cardiovascular risk factors are controlled for, the variation of the discrete trait CAP is under appreciable additive genetic influences.
引用
收藏
页码:2775 / 2780
页数:6
相关论文
共 10 条
[1]   Increased common carotid intima-media thickness - Adaptive response or a reflection of atherosclerosis? Findings from the Rotterdam study [J].
Bots, ML ;
Hofman, A ;
Grobbee, DE .
STROKE, 1997, 28 (12) :2442-2447
[2]   CARDIOVASCULAR DETERMINANTS OF CAROTID-ARTERY DISEASE - THE ROTTERDAM ELDERLY STUDY [J].
BOTS, ML ;
BRESLAU, PJ ;
BRIET, E ;
DEBRUYN, AM ;
VANVLIET, HHDM ;
VANDENOUWELAND, FA ;
DEJONG, PTVM ;
HOFMAN, A ;
GROBBEE, DE .
HYPERTENSION, 1992, 19 (06) :717-720
[3]   Risk factors differ for carotid artery plaque with and without acoustic shadowing [J].
Duncan, BB ;
Sharrett, AR ;
Tegeler, C ;
Tyroler, HA ;
Metcalf, P ;
Heiss, G ;
Crouse, JR ;
Li, RL .
JOURNAL OF NEUROIMAGING, 1997, 7 (01) :28-34
[4]  
GLAGOV S, 1988, ARCH PATHOL LAB MED, V112, P1018
[5]   CAROTID ATHEROSCLEROSIS MEASURED BY B-MODE ULTRASOUND IN POPULATIONS - ASSOCIATIONS WITH CARDIOVASCULAR RISK-FACTORS IN THE ARIC STUDY [J].
HEISS, G ;
SHARRETT, AR ;
BARNES, R ;
CHAMBLESS, LE ;
SZKLO, M ;
ALZOLA, C .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1991, 134 (03) :250-256
[6]  
HOPKINS PN, 1989, ANNU REV NUTR, V9, P303
[7]   B-MODE-DETECTED CAROTID-ARTERY PLAQUE IN A GENERAL-POPULATION [J].
LI, RL ;
DUNCAN, BB ;
METCALF, PA ;
CROUSE, JR ;
SHARRETT, AR ;
TYROLER, HA ;
BARNES, R ;
HEISS, G .
STROKE, 1994, 25 (12) :2377-2383
[8]   ULTRASONOGRAPHICALLY ASSESSED CAROTID MORPHOLOGY AND THE RISK OF CORONARY HEART-DISEASE [J].
SALONEN, JT ;
SALONEN, R .
ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (05) :1245-1249
[9]   DETERMINANTS OF CAROTID INTIMA-MEDIA THICKNESS - A POPULATION-BASED ULTRASONOGRAPHY STUDY IN EASTERN FINNISH MEN [J].
SALONEN, R ;
SALONEN, JT .
JOURNAL OF INTERNAL MEDICINE, 1991, 229 (03) :225-231
[10]   Differential association of common carotid intima-media thickness and carotid atherosclerotic plaques with parental history of premature death from coronary heart disease -: The EVA study [J].
Zureik, M ;
Touboul, PJ ;
Bonithon-Kopp, C ;
Courbon, D ;
Ruelland, I ;
Ducimetière, P .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (02) :366-371