An amyloid-like cascade hypothesis for C9orf72 ALS/FTD

被引：57

作者：

Edbauer, Dieter ^{[1
,2
,3
]}

Haass, Christian ^{[1
,2
,4
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Feodor Lynen Str 17, D-81377 Munich, Germany

[2] Munich Cluster Syst Neurol SyNergy, Feodor Lynen Str 17, D-81377 Munich, Germany

[3] Univ Munich, D-81377 Munich, Germany

[4] Univ Munich, Biomed Ctr BMC, Feodor Lynen Str 17, D-81377 Munich, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2016年 / 36卷

基金：

欧洲研究理事会;

关键词：

FRONTOTEMPORAL LOBAR DEGENERATION; AMYOTROPHIC-LATERAL-SCLEROSIS; DIPEPTIDE REPEAT PROTEINS; NUCLEAR-RNA FOCI; HEXANUCLEOTIDE REPEAT; EXPANDED C9ORF72; MOTOR-NEURONS; ANTISENSE TRANSCRIPTS; ALZHEIMERS-DISEASE; TARDBP MUTATIONS;

D O I：

10.1016/j.conb.2015.10.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expansion of a GGGGCC repeat in C9orf72 causes amyotrophic lateral sclerosis, frontotemporal dementia, or a combination of both. Bidirectional repeat transcripts sequester RNA-binding proteins into nuclear RNA foci. The repeat is translated into dipeptide repeat (DPR) proteins that are crucial for repeat-induced toxicity. DPRs inhibit the proteasome and sequester other proteins. These changes are accompanied by widespread brain atrophy and subclinical cognitive impairment before disease onset. Both repeat RNA and DPRs impair nucleocytoplasmic transport and promote TDP-43 mislocalization and aggregation. Thus, repeat RNA and DPRs may gradually trigger TDP-43 pathology and subsequent region-specific neurodegeneration in a cascade similar to amyloid-p peptide in Alzheimer's disease. The key components of the C9orf72 cascade are promising therapeutic targets in different disease stages.

引用

页码：99 / 106

页数：8

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