Can involved-field irradiation replace elective nodal irradiation in chemoradiotherapy for esophageal cancer? A systematic review and meta-analysis

被引：20

作者：

Wang, Xiaoyue ^{[1
]}

Miao, Chuanwang ^{[2
,3
]}

Chen, Zhen ^{[4
]}

Li, Wanhu ^{[5
]}

Yuan, Shuanghu ^{[3
]}

Yu, Jinming ^{[3
]}

Hu, Xudong ^{[3
]}

机构：

[1] Shandong Univ, Shandong Canc Hosp, Dept Surg, Jinan, Shandong, Peoples R China

[2] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Dept Oncol, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Shandong Canc Hosp, Dept Radiat Oncol, 440 Jiyan Rd, Jinan 250117, Shandong, Peoples R China

[4] Shandong Univ, Shandong Canc Hosp, Dept Med Oncol, Jinan, Shandong, Peoples R China

[5] Shandong Univ, Shandong Canc Hosp, Dept Radiol, Jinan, Shandong, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2017年 / 10卷

关键词：

chemoradiotherapy; esophageal cancer; involved-field irradiation; elective nodal irradiation; meta-analysis; SQUAMOUS-CELL CARCINOMA; RADIATION-THERAPY; RADIOTHERAPY; OUTCOMES; TRIAL; ENI;

D O I：

10.2147/OTT.S130285

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chemoradiotherapy is the most common treatment for inoperable esophageal cancer. However, there is no consensus on the delineation of the clinical target volume. Elective nodal irradiation (ENI) is recommended for inoperable esophageal cancer. A few studies have reported a decrease in the incidence of radiation-related toxicity of involved-field irradiation (IFI) for esophageal cancer. A systematic review and pooled analysis were performed to determine whether IFI in definitive chemoradiotherapy was more beneficial than ENI for esophageal cancer. The results showed no significant differences in the overall survival and local control rates between the IFI and ENI arms. Meanwhile, the incidences of esophageal and lung toxicities were significantly decreased in the IFI arm. These results suggest that IFI is a feasible treatment option for locally advanced esophageal cancer, especially to minimize irradiation-related toxicity.

引用

页码：2087 / 2095

页数：9

共 21 条

[1]

[Anonymous], DIS ESOPHAGUS

[2] Hodgkin Lymphoma: Diagnosis and Treatment [J].

Ansell, Stephen M. .

MAYO CLINIC PROCEEDINGS, 2015, 90 (11) :1574-1583

[3] Involved-field radiotherapy alone for early-stage non-small-cell lung cancer [J].

Cheung, PCF ;

Mackillop, WJ ;

Dixon, P ;

Brundage, MD ;

Youssef, YM ;

Zhou, S .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2000, 48 (03) :703-710

[4] Chemoradiotherapy of locally advanced esophageal cancer - Long-term follow-up of a prospective randomized trial (RTOG 85-01) [J].

Cooper, JS ;

Guo, MD ;

Herskovic, A ;

Macdonald, JS ;

Martenson, JA ;

Al-Sarraf, M ;

Byhardt, R ;

Russell, AH ;

Beitler, JJ ;

Spencer, S ;

Asbell, SO ;

Graham, MV ;

Leichman, LL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (17) :1623-1627

[5] Chemoradiation in oesophageal cancer [J].

Dai, Tong ;

Shah, Manish A. .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2015, 29 (01) :193-209

[6] Definitive, Preoperative, and Palliative Radiation Therapy of Esophageal Cancer [J].

Fokas, Emmanouil ;

Roedel, Claus .

VISZERALMEDIZIN, 2015, 31 (05) :347-353

[7] Feasibility of Elective Nodal Irradiation (ENI) and Involved Field Irradiation (IFI) in Radiotherapy for the Elderly Patients (Aged ≥ 70 Years) with Esophageal Squamous Cell Cancer: A Retrospective Analysis from a Single Institute [J].

Jing, Wang ;

Zhu, Hui ;

Guo, Hongbo ;

Zhang, Yan ;

Shi, Fang ;

Han, Anqin ;

Li, Minghuan ;

Kong, Li ;

Yu, Jinming .

PLOS ONE, 2015, 10 (12)

[8] Patterns of Failure Associated with Involved Field Radiotherapy in Patients with Clinical Stage I Thoracic Esophageal Cancer [J].

Kawaguchi, Yoshifumi ;

Nishiyama, Kinji ;

Miyagi, Ken ;

Suzuki, Osamu ;

Ito, Yuri ;

Nakamura, Satoaki .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 41 (08) :1007-1012

[9] Involved-field irradiation in definitive chemoradiotherapy for T4 squamous cell carcinoma of the esophagus [J].

Li, M. ;

Zhao, F. ;

Zhang, X. ;

Shi, F. ;

Zhu, H. ;

Han, A. ;

Zhang, Y. ;

Kong, L. ;

Yu, J. .

CURRENT ONCOLOGY, 2016, 23 (02) :E131-E137

[10] Involved-Field Irradiation vs Elective Nodal Irradiation for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma: A Comparative Interim Analysis of Clinical Outcomes and Toxicities (NCT01551589, CSWOG 003) [J].

Li, T. ;

Yisikandaer, A. ;

Zhang, X. ;

Wang, X. ;

Ma, Y. ;

Chen, L. ;

Lu, B. ;

Chen, H. ;

Yang, J. ;

Lv, J. ;

Lang, J. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2015, 93 (03) :S3-S4

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