Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota

被引：118
|
作者：
Hoefs, Sarah [1 ]
Mogavero, Selene [1 ]
Hube, Bernhard [1 ,2 ,3 ]
机构：
[1] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, Dept Microbial Pathogen Mech, Jena, Germany
[2] Univ Jena, Jena, Germany
[3] Univ Hosp, Ctr Sepsis Control & Care, Jena, Germany
来源：
JOURNAL OF MICROBIOLOGY | 2016年 / 54卷 / 03期
关键词：
host response; fungal infection; adhesion; morphogenesis; biofilm; fungal-bacterial interactions; C-TYPE LECTIN; CHRONIC MUCOCUTANEOUS CANDIDIASIS; INTESTINAL EPITHELIAL BARRIER; IMMUNOGLOBULIN-G ANTIBODIES; STAPHYLOCOCCUS-AUREUS; TRANSGLUTAMINASE SUBSTRATE; PSEUDOMONAS-AERUGINOSA; ADAPTIVE IMMUNITY; BIOFILM FORMATION; HYPHAL FORMATION;
D O I：
10.1007/s12275-016-5514-0
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The interaction between Candida albicans and its host cells is characterized by a complex interplay between the expression of fungal virulence factors, which results in adherence, invasion and cell damage, and the host immune system, which responds by secreting proinflammatory cytokines, activating antimicrobial activities and killing the fungal pathogen. In this review we describe this interplay by taking a closer look at how C. albicans pathogenicity is induced and executed, how the host responds in order to prevent and clear an infection, and which mechanisms C. albicans has evolved to bypass these immune responses to avoid clearance. Furthermore, we review studies that show how the presence of other microorganisms affects this interplay.
引用
收藏
页码：149 / 169
页数：21
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