Treating obesity: Does antagonism of NPY fit the bill?

被引：3

作者：

Farooqi, Sadaf ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England

来源：

CELL METABOLISM | 2006年 / 4卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.cmet.2006.09.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this issue of Cell Metabolism, Erondu et al. (2006) identify a selective neuropeptide Y5 receptor antagonist that, as predicted from rodent studies, results in weight loss when administered to overweight and obese human subjects. In a one-year randomized placebo-controlled clinical trial, the weight loss was modest; the results support the emerging concept that NPY acts via overlapping and redundant energy homeostasis pathways.

引用

页码：260 / 262

页数：3

共 10 条

[1] Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus
Baskin, DG
Breininger, JF
Schwartz, MW
[J]. DIABETES, 1999, 48 (04) : 828 - 833
[2] Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults
Erondu, Ngozi
Gantz, Ira
Musser, Bret
Suryawanshi, Shailaja
Mallick, Madhuja
Addy, Carol
Cote, Josee
Bray, George
Fujioka, Ken
Bays, Harold
Hollander, Priscilla
Sanabria-Bohorquez, Sandra M.
Eng, WaiSi
Langstrom, Bengt
Hargreaves, Richard J.
Burns, H. Donald
Kanatani, Akio
Fukami, Takehiro
MacNeil, Douglas J.
Gottesdiener, Keith M.
Amatruda, John M.
Kaufman, Keith D.
Heymsfield, Steven B.
[J]. CELL METABOLISM, 2006, 4 (04) : 275 - 282
[3] Distribution of NPY receptors in the hypothalamus
Fetissov, SO
Kopp, J
Hökfelt, T
[J]. NEUROPEPTIDES, 2004, 38 (04) : 175 - 188
[4] Overweight and obesity in the United States: prevalence and trends, 1960-1994
Flegal, KM
Carroll, MD
Kuczmarski, RJ
Johnson, CL
[J]. INTERNATIONAL JOURNAL OF OBESITY, 1998, 22 (01) : 39 - 47
[5] LIN EJ, 2006, ENDOCRINOLOGY 0727, DOI DOI 10.1210/EN.2006-0097
[6] NPY and Y receptors: lessons from transgenic and knockout models
Lin, S
Boey, D
Herzog, H
[J]. NEUROPEPTIDES, 2004, 38 (04) : 189 - 200
[7] Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status
Parker, E
Van Heek, M
Stamford, A
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 440 (2-3) : 173 - 187
[8] [D-Trp34] neuropeptide Y is a potent and selective neuropeptide YY5 receptor agonist with dramatic effects on food intake
Parker, EM
Balasubramaniam, A
Guzzi, M
Mullins, DE
Salisbury, BG
Sheriff, S
Witten, MB
Hwa, JJ
[J]. PEPTIDES, 2000, 21 (03) : 393 - 399
[9] Clinical trial issues in weight-loss therapy
Patel, MR
Donahue, M
Wilson, PWF
Califf, RM
[J]. AMERICAN HEART JOURNAL, 2006, 151 (03) : 633 - 642
[10] Central nervous system control of food intake
Schwartz, MW
Woods, SC
Porte, D
Seeley, RJ
Baskin, DG
[J]. NATURE, 2000, 404 (6778) : 661 - 671

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