The Mannich-Type Synthesis of Macroheterocycles with Pyrido[2,1-b][1,3,5]thiadiazine Unit

被引：9

作者：

Dotsenko, Victor V. ^{[1
]}

Chigorina, Elena A. ^{[2
]}

Papaianina, Elena S. ^{[3
]}

Frolov, Konstantin A. ^{[4
,5
]}

Krivokolysko, Sergey G. ^{[4
,5
]}

机构：

[1] Kuban State Univ, Krasnodar 350040, Russia

[2] Fed State Unitary Enterprise Res Inst Chem Reacta, Moscow 107076, Russia

[3] Univ Erlangen Nurnberg, Inst Organ Chem 2, D-91054 Erlangen, Germany

[4] Lugansk State Med Univ, Lugansk 91045, Lugansk Peoples, Ukraine

[5] Vladimir Dal Lugansk Univ, ChemEx Lab, Lugansk 91034, Lugansk Peoples, Ukraine

来源：

MACROHETEROCYCLES | 2015年 / 8卷 / 03期

关键词：

Cyanothioacetamide; pyridine-2-thiolates; Guareschi-Thorpe reaction; pyrido[2,1-b][1,3,5]thiadiazines; Mannich reaction; diamines; CP/MAS NMR C-13 spectra;

D O I：

10.6060/mhc150870d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New macrocyclic products containing four pyrido[2,1-b][1,3,5]thiadiazine units linked by methylene bridges and phenylene spacers were synthesized by reaction of morpholinium 3-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-thiolate with aromatic diamines (p-phenylenediamine, benzidine) and excess of HCHO. A rapid solvent-free procedure for synthesis of the starting thiolate was proposed. The structure of the products was confirmed by IR-, solid state NMR C-13 data and elemental analysis.

引用

页码：310 / 313

页数：4

共 13 条

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