Antigenic targets of CAR T Cell Therapy. A retrospective view on clinical trials

被引：31

作者：

Arabi, Fatemeh ^{[1
]}

Torabi-Rahvar, Monireh ^{[1
]}

Shariati, Ali ^{[1
]}

Ahmadbeigi, Naser ^{[2
]}

Naderi, Mahmood ^{[2
]}

机构：

[1] SABZ Biomed Sci Based Co, Tehran, Iran

[2] Univ Tehran Med Sci, Shariati Hosp, Digest Dis Res Inst, Cell Based Therapies Res Ctr, North Kargar Ave, Tehran 14117, Iran

来源：

EXPERIMENTAL CELL RESEARCH | 2018年 / 369卷 / 01期

关键词：

CARs; Chimeric antigen receptors; Tumor antigens; Immunotherapy; Adoptive T cell transfer; PHASE-I; ADOPTIVE IMMUNOTHERAPY; MATURATION ANTIGEN; ANTITUMOR-ACTIVITY; RECEPTOR; CANCER; LYMPHOMA; SUPPRESSION; LYMPHOCYTES; TOXICITIES;

D O I：

10.1016/j.yexcr.2018.05.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chimeric antigen receptor (CAR) T cell therapy is anticipated to be increasingly implemented in the context of cancer treatment after two current FDA approval of anti-CD19 CAR-T cells (Kymriah (TM)& Yescarta (TM)). The success of CD19 is mainly attributable to the proper selection of the antigen, CD19, as the target of the disease, highlighting the importance of target selection for other CAR therapies. Therefore, here we performed a global analysis of targets that are the prime focus for various CAR T cell therapies in human clinical trials.

引用

页码：1 / 10

页数：10

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