Efficient coupling and solid-phase synthesis of steroidal ketone derivative using polymer-bound glycerol

被引：15

作者：

Maltais, R ^{[1
]}

Bérubé, M ^{[1
]}

Marion, O ^{[1
]}

Labrecque, R ^{[1
]}

Poirier, D ^{[1
]}

机构：

[1] Univ Laval, Med Res Ctr, Mol Endocrinol Lab, Div Med Chem, Quebec City, PQ G1V 4G2, Canada

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 11期

基金：

英国医学研究理事会;

关键词：

solid-phase synthesis; acetals; steroids; ketones;

D O I：

10.1016/S0040-4039(00)00050-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High-yield coupling of steroidal hindered ketones onto polymer-bound glycerol by an efficient acetal exchange reaction is reported under mild conditions. A solid-phase model sequence of five steps is thereafter achieved to synthesize a steroidal ketone derivative having two levels of diversity in good yield and purity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1691 / 1694

页数：4

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