Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

被引：132

作者：

Bachmann, Nadine ^{[1
,2
]}

von Siebenthal, Chantal ^{[1
,2
]}

Vongrad, Valentina ^{[1
,2
]}

Turk, Teja ^{[1
,2
]}

Neumann, Kathrin ^{[1
,2
]}

Beerenwinkel, Niko ^{[3
,4
]}

Bogojeska, Jasmina ^{[5
]}

Fellay, Jaques ^{[6
,7
]}

Roth, Volker ^{[8
]}

Kok, Yik Lim ^{[1
,2
]}

Thorball, Christian W. ^{[6
]}

Borghesi, Alessandro ^{[6
,9
]}

Parbhoo, Sonali ^{[8
]}

Wieser, Mario ^{[8
]}

Boni, Jurg ^{[2
]}

Perreau, Matthieu ^{[10
]}

Klimkait, Thomas ^{[11
]}

Yerly, Sabine ^{[12
,13
]}

Battegay, Manuel ^{[14
,15
]}

Rauch, Andri ^{[16
]}

Hoffmann, Matthias ^{[17
]}

Bernasconi, Enos ^{[18
]}

Cavassini, Matthias ^{[19
]}

Kouyos, Roger D. ^{[1
,2
]}

Gunthard, Huldrych F. ^{[1
,2
]}

Metzner, Karin J. ^{[1
,2
]}

Anagnostopoulos, Alexia ^{[1
]}

Braun, Dominique L. ^{[1
,14
,15
]}

Bucher, Heiner C. ^{[18
,20
]}

Calmy, Alexandra ^{[12
,13
]}

Ciuffi, Angela ^{[21
]}

Dollenmaier, Gunter ^{[22
]}

Egger, Matthias ^{[23
]}

Elzi, Luigia ^{[12
,13
]}

Fehr, Jan ^{[1
]}

Fellay, Jacques ^{[6
,7
]}

Furrer, Hansjakob ^{[14
,15
]}

Fux, Christoph A. ^{[24
,25
]}

Haerry, David ^{[26
]}

Hasse, Barbara ^{[1
]}

Hirsch, Hans H. ^{[10
,12
,13
]}

Hosli, Irene ^{[27
]}

Huber, Michael ^{[2
]}

Kahlert, Christian ^{[16
,28
]}

Kaiser, Laurent ^{[11
]}

Keiser, Olivia ^{[23
]}

Kovari, Helen ^{[1
]}

Ledergerber, Bruno ^{[1
]}

Martinetti, Gladys ^{[29
]}

de Tejada, Begona Martinez ^{[30
]}

机构：

[1] Univ Hosp Zurich, Dept Infect Dis & Hosp Epidemiol, CH-8091 Zurich, Switzerland

[2] Univ Zurich, Inst Med Virol, CH-8057 Zurich, Switzerland

[3] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland

[4] SIB, CH-4057 Basel, Switzerland

[5] IBM Res Zurich, CH-8803 Ruschlikon, Switzerland

[6] Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland

[7] Lausanne Univ Hosp, Precis Med Unit, CH-1011 Lausanne, Switzerland

[8] Univ Basel, Dept Math & Comp Sci, CH-4001 Basel, Switzerland

[9] Fdn IRCCS Policlin San Matteo, Neonatal Intens Care Unit, I-27100 Pavia, Italy

[10] Univ Lausanne, CHU Vaudois, Div Immunol & Allergy, CH-1015 Lausanne, Switzerland

[11] Univ Basel, Dept Biomed Peterspl, Div Infect Diagnost, CH-4001 Basel, Switzerland

[12] Univ Geneva, Univ Hosp Geneva, Div Infect Dis, CH-1211 Geneva, Switzerland

[13] Univ Geneva, Lab Virol, Univ Hosp Geneva, CH-1211 Geneva, Switzerland

[14] Univ Hosp Basel, Dept Infect Dis, CH-4031 Basel, Switzerland

[15] Univ Hosp Basel, Hosp Epidemiol, CH-4031 Basel, Switzerland

[16] Univ Hosp Bern, Dept Infect Dis, CH-3010 Bern, Switzerland

[17] Cantonal Hosp St Gallen, Div Infect Dis, CH-9007 St Gallen, Switzerland

[18] Reg Hosp, Infect Dis Serv, CH-6900 Lugano, Switzerland

[19] Univ Lausanne, CHU Vaudois, Div Infect Dis, CH-1015 Lausanne, Switzerland

[20] Univ Basel, Univ Hosp Basel, Basel Inst Clin Epidemiol & Biostat, Basel, Switzerland

[21] Univ Lausanne, Univ Hosp Lausanne, Inst Microbiol, Lausanne, Switzerland

[22] Canton St Gallen, Ctr Lab Med, St Gallen, Switzerland

[23] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

[24] Kantonsspital Aarau, Clin Infect Dis, Aarau, Switzerland

[25] Kantonsspital Aarau, Hosp Hyg, Aarau, Switzerland

[26] Posit Council, Zurich, Switzerland

[27] Univ Basel, Univ Hosp Basel, Clin Obstet, Basel, Switzerland

[28] Childrens Hosp Eastern Switzerland, St Gallen, Switzerland

[29] Cantonal Inst Microbiol, Bellinzona, Switzerland

[30] Univ Geneva, Univ Hosp Geneva, Dept Obstet & Gynecol, Geneva, Switzerland

[31] Univ Zurich, Univ Childrens Hosp, Zurich, Switzerland

[32] Univ Basel, Univ Childrens Hosp, Basel, Switzerland

[33] Univ Basel, Kantonsspital Baselland, Basel, Switzerland

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

瑞士国家科学基金会;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; REPLICATION-COMPETENT HIV-1; HEPATITIS-C VIRUS; PLASMA VIRAL LOAD; CD4(+) T-CELLS; ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; INTERFERON-ALPHA; LATENT RESERVOIR; IN-VIVO;

D O I：

10.1038/s41467-019-10884-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.

引用

页数：11

共 68 条

[1] HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART [J].