A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

被引：17

作者：

Harris, ZL

Davis-Kaplan, SR

Gitlin, JD

Kaplan, J ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USA

[2] Johns Hopkins Univ, Sch Med, Dept Anesthesiol, Baltimore, MD USA

[3] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

来源：

BLOOD | 2004年 / 103卷 / 12期

关键词：

D O I：

10.1182/blood-2003-11-4060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism. (C) 2004 by The American Society of Hematology.

引用

页码：4672 / 4673

页数：2