Repurposing anticancer drugs for the management of COVID-19

被引：61

作者：

El Bairi, Khalid ^{[1
]}

Trapani, Dario ^{[2
]}

Petrillo, Angelica ^{[3
,4
]}

Le Page, Cecile ^{[5
]}

Zbakh, Hanaa ^{[6
]}

Daniele, Bruno ^{[3
]}

Belbaraka, Rhizlane ^{[7
]}

Curigliano, Giuseppe ^{[2
,8
]}

Afqir, Said ^{[1
]}

机构：

[1] Mohammed VI Univ Hosp, Dept Med Oncol, Oujda, Morocco

[2] IRCCS, European Inst Oncol, Milan, Italy

[3] Osped Mare, Med Oncol Unit, Naples, Italy

[4] Univ Study Campania L Vanvitelli, Naples, Italy

[5] McGill Univ, Hlth Ctr RI MUHC, Res Inst, Montreal, PQ, Canada

[6] Univ Algarve, Ctr Marine Sci, Ed 7,Campus Gambelas, P-8005139 Faro, Portugal

[7] Cadi Ayad Univ, Fac Med, Biosci & Sante Res Lab, Dept Med Oncol, Marrakech, Morocco

[8] Univ Milan, Dept Oncol & Hematol, Milan, Italy

来源：

EUROPEAN JOURNAL OF CANCER | 2020年 / 141卷

关键词：

COVID-19; SARS-CoV-2; Anticancer drugs; Repurposing; RESPIRATORY SYNDROME CORONAVIRUS; SPHINGOSINE KINASE 2; PLACEBO-CONTROLLED TRIAL; BRUTONS TYROSINE KINASE; SARACATINIB AZD0530; NATURAL COMPOUNDS; THERAPY RESPONSE; ORAL SELINEXOR; DENGUE VIRUS; DOUBLE-BLIND;

D O I：

10.1016/j.ejca.2020.09.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded as a global public health emergency. The existing therapeutic options for COVID-19 beyond the intensive supportive care are limited, with an undefined or modest efficacy reported so far. Drug repurposing represents an enthusiastic mechanism to use approved drugs outside the scope of their original indication and accelerate the discovery of new therapeutic options. With the emergence of COVID-19, drug repurposing has been largely applied for early clinical testing. In this review, we discuss some repurposed anticancer drugs for the treatment of COVID-19, which are under investigation in clinical trials or proposed for the clinical testing. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：40 / 61

页数：22

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