Can We Improve Fixation and Outcomes in the Treatment of Femoral Neck Fractures? The Use of Pharmaceuticals

被引：18

作者：

Kakar, Sanieey ^{[1
]}

Little, David ^{[2
]}

Einhorn, Thomas A. ^{[1
]}

机构：

[1] Boston Univ, Med Ctr, Dept Orthopaed Surg, Boston, MA 02118 USA

[2] Childrens Hosp, Dept Orthopaed, Westmead, NSW, Australia

来源：

JOURNAL OF ORTHOPAEDIC TRAUMA | 2009年 / 23卷 / 06期

关键词：

parathyroid hormone; bisphosphonates; hip fractures; PARATHYROID-HORMONE; 1-34; TOTAL HIP-ARTHROPLASTY; BONE-MINERAL CONTENT; INTERNAL-FIXATION; SUBCAPITAL FRACTURES; MECHANICAL STRENGTH; INTRACAPSULAR FRACTURES; POSTMENOPAUSAL WOMEN; MEVALONATE PATHWAY; IMPLANT FIXATION;

D O I：

10.1097/BOT.0b013e3181ac64a0

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Femoral neck fracture rates are on the rise with an estimated 500,000 occurring annually by 2040. Despite the mainstay of open reduction and internal fixation, nonunion rates Of Lip to 33% have been reported for displaced femoral neck fractures. Recently, increasing attention has been focused upon the role of osteobiologics to stimulate fracture repair. This article looks at the role of these anabolic compounds and discusses their potential future roles in augmenting the treatment of this condition.

引用

页码：413 / 421

页数：9

共 83 条

[41]

GARDEN RS, 1974, ORTHOP CLIN N AM, V5, P683

[42] The relative merits of anabolics versus anti-resorptive compounds: where our targets should be, and whether we are addressing them [J].

Gasser, Jurg A. .

CURRENT OPINION IN PHARMACOLOGY, 2006, 6 (03) :313-318

[43] The complications of displaced intracapsular fractures of the hip [J].

Gurusamy, K ;

Parker, MJ ;

Rowlands, TK .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2005, 87B (05) :632-634

[44] Are patients with a nonunion after a femoral neck fracture more osteoporotic than others?: BMD measurement before the choice of treatment?: A pilot study of hip BMD and biochemical bone markers in patients with femoral neck fractures [J].

Hedström, M .

ACTA ORTHOPAEDICA SCANDINAVICA, 2004, 75 (01) :50-52

[45] Clodronate prevents prosthetic migration - A randomized radiostereometric study of 50 total knee patients [J].

Hilding, M ;

Ryd, L ;

Toksvig-Larsen, S ;

Aspenberg, P .

ACTA ORTHOPAEDICA SCANDINAVICA, 2000, 71 (06) :553-557

[46] EFFECTS OF CONTINUOUS AND INTERMITTENT ADMINISTRATION AND INHIBITION OF RESORPTION ON THE ANABOLIC RESPONSE OF BONE TO PARATHYROID-HORMONE [J].

HOCK, JM ;

GERA, I .

JOURNAL OF BONE AND MINERAL RESEARCH, 1992, 7 (01) :65-72

[47] Internal fixation versus total hip arthroplasty in the treatment of displaced femoral neck fractures -: A prospective randomized study of 100 hips [J].

Johansson, T ;

Jacobsson, SA ;

Ivarsson, I ;

Knutsson, A ;

Wahlström, O .

ACTA ORTHOPAEDICA SCANDINAVICA, 2000, 71 (06) :597-602

[48]

Juppner H., 2003, PRIMER METABOLIC BON, V5th, P117

[49] Internal fixation of femoral neck fractures with posterior comminution: A biomechanical study [J].

Kauffman, JI ;

Simon, JA ;

Kummer, FJ ;

Pearlman, CJ ;

Zuckerman, JD ;

Koval, KJ .

JOURNAL OF ORTHOPAEDIC TRAUMA, 1999, 13 (03) :155-159

[50] Relevance of primary reduction for the clinical outcome of femoral neck fractures treated with cancellous screws [J].

Krischak, G ;

Beck, A ;

Wachter, N ;

Jakob, R ;

Kinzl, L ;

Suger, G .

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 2003, 123 (08) :404-409

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