Can We Improve Fixation and Outcomes in the Treatment of Femoral Neck Fractures? The Use of Pharmaceuticals

被引：18

作者：

Kakar, Sanieey ^{[1
]}

Little, David ^{[2
]}

Einhorn, Thomas A. ^{[1
]}

机构：

[1] Boston Univ, Med Ctr, Dept Orthopaed Surg, Boston, MA 02118 USA

[2] Childrens Hosp, Dept Orthopaed, Westmead, NSW, Australia

来源：

JOURNAL OF ORTHOPAEDIC TRAUMA | 2009年 / 23卷 / 06期

关键词：

parathyroid hormone; bisphosphonates; hip fractures; PARATHYROID-HORMONE; 1-34; TOTAL HIP-ARTHROPLASTY; BONE-MINERAL CONTENT; INTERNAL-FIXATION; SUBCAPITAL FRACTURES; MECHANICAL STRENGTH; INTRACAPSULAR FRACTURES; POSTMENOPAUSAL WOMEN; MEVALONATE PATHWAY; IMPLANT FIXATION;

D O I：

10.1097/BOT.0b013e3181ac64a0

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Femoral neck fracture rates are on the rise with an estimated 500,000 occurring annually by 2040. Despite the mainstay of open reduction and internal fixation, nonunion rates Of Lip to 33% have been reported for displaced femoral neck fractures. Recently, increasing attention has been focused upon the role of osteobiologics to stimulate fracture repair. This article looks at the role of these anabolic compounds and discusses their potential future roles in augmenting the treatment of this condition.

引用

页码：413 / 421

页数：9

共 83 条

[1] RELEVANCE OF OSTEOPOROSIS IN WOMEN WITH FRACTURE OF THE FEMORAL-NECK [J].

AITKEN, JM .

BMJ-BRITISH MEDICAL JOURNAL, 1984, 288 (6417) :597-601

[2]

ALBERTS KA, 1990, CLIN ORTHOP RELAT R, P129

[3] PREDICTION OF FIXATION FAILURE IN FEMORAL-NECK FRACTURES - COMMINUTION AND AVASCULARITY STUDIED IN 40 PATIENTS [J].

ALHO, A ;

BENTERUD, JG ;

MULLER, C ;

HUSBY, T .

ACTA ORTHOPAEDICA SCANDINAVICA, 1993, 64 (04) :408-410

[4] Internally fixed femoral neck fractures - Early prediction of failure in 203 elderly patients with displaced fractures [J].

Alho, A ;

Benterud, JG ;

Solovieva, S .

ACTA ORTHOPAEDICA SCANDINAVICA, 1999, 70 (02) :141-144

[5] Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34) [J].

Alkhiary, YM ;

Gerstenfeld, LC ;

Krall, E ;

Westmore, M ;

Sato, M ;

Mitlak, BH ;

Einhorn, TA .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2005, 87A (04) :731-741

[6] A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair [J].

Amanat, N ;

Brown, R ;

Bilston, LE ;

Little, DG .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2005, 23 (05) :1029-1034

[7] Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures [J].

Andreassen, TT ;

Ejersted, C ;

Oxlund, H .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (06) :960-968

[8] Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone [J].

Andreassen, TT ;

Fledelius, C ;

Ejersted, C ;

Oxlund, H .

ACTA ORTHOPAEDICA SCANDINAVICA, 2001, 72 (03) :304-307

[9]

[Anonymous], NAT OST FDN GUID

[10]

[Anonymous], AM J RADIOL

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