CLINICAL TRIAL ENDPOINTS FOR OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

被引：32
作者：
Cole, Emily D. [1 ,2 ,3 ]
Ferrara, Daniela [1 ]
Novais, Eduardo A. [1 ,4 ]
Louzada, Ricardo N. [1 ,5 ]
Waheed, Nadia K. [1 ]
机构：
[1] Tufts Med Ctr, New England Eye Ctr, 260 Tremont St,Biewend Bldg,9-11th Floor, Boston, MA 02116 USA
[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[3] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[4] Univ Fed Goias, Goiania, Go, Brazil
[5] Univ Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
来源：
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2016年 / 36卷 / 12期
关键词：
optical coherence tomography; optical coherence tomography angiography; neovascular age-related macular degeneration; ENDOTHELIAL GROWTH-FACTOR; CHOROIDAL NEOVASCULARIZATION; ULTRAHIGH-SPEED; OCT ANGIOGRAPHY; TYPE-2; NEOVASCULARIZATION; QUANTITATIVE-ANALYSIS; IMAGE ARTIFACTS; DOSING REGIMEN; RANIBIZUMAB; THERAPY;
D O I：
10.1097/IAE.0000000000001338
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: To describe qualitative and quantitative optical coherence tomography (OCT) angiography (OCTA) parameters for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and their applicability as potential clinical trial endpoints. Methods: A review of current literature related to the topic of OCTA and AMD. Results: There are a number of promising OCTA parameters that can be used to diagnose the presence of CNV and to monitor the activity and progression of the lesion, pre- and post-treatment morphological characteristics, CNV dimensions, and automated quantitative parameters such as vessel density. Conclusion: The OCTA parameters described in this review have promise for the future development of clinical trial endpoints, but require further validation before they can be widely used.
引用
收藏
页码：S83 / S92
页数：10
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