Stem Cell Therapy to Treat Heart Ischaemia: Implications for Diabetes Cardiovascular Complications

被引：7
作者：
Qayyum, Abbas Ali [1 ,2 ,3 ]
Mathiasen, Anders Bruun [1 ,2 ,3 ]
Kastrup, Jens [1 ,2 ,3 ]
机构：
[1] Copenhagen Univ Hosp, Rigshosp, Ctr Heart, Cardiac Catheterizat Lab 2014, DK-2100 Copenhagen O, Denmark
[2] Copenhagen Univ Hosp, Rigshosp, Ctr Heart, Cardiac Stem Cell Lab, DK-2100 Copenhagen O, Denmark
[3] Fac Hlth Sci, DK-2100 Copenhagen O, Denmark
来源：
CURRENT DIABETES REPORTS | 2012年 / 14卷 / 12期
关键词：
Cardiovascular complications; Coronary artery disease; Diabetes mellitus; Mesenchymal stem cell; Myocardial ischaemia; Stem cells; ACUTE MYOCARDIAL-INFARCTION; MESENCHYMAL STROMAL CELLS; CORONARY-ARTERY-DISEASE; BONE-MARROW; REFRACTORY ANGINA; CARDIAC-DISEASE; DOUBLE-BLIND; FOLLOW-UP; METAANALYSIS; FAILURE;
D O I：
10.1007/s11892-014-0554-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes mellitus is a well-known risk factor for coronary artery disease (CAD), which can lead to acute myocardial infarction, chronic myocardial ischaemia and heart failure. Despite the advantages in medical treatment, percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), morbidity and mortality is still high in patients with CAD. Along with PCI and CABG or in patients without options for revascularization, stem cell regenerative therapy in controlled trials is a possibility. Stem cells are believed to exert their actions by angiogenesis and regeneration of cardiomyocytes. Recently published clinical trials and meta-analysis of stem cell studies have shown encouraging results with increased left ventricle ejection fraction and reduced symptoms in patients with CAD and heart failure. There is some evidence of mesenchymal stem cell being more effective compared to other cell types and cell therapy may be more effective in patients with known diabetes mellitus. However, further investigations are warranted.
引用
收藏
页码：554 / U29
页数：8
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