A novel approach to reversal of neuromuscular blockade

被引：0

作者：

Della Rocca, G. ^{[1
]}

Pompei, L. ^{[1
]}

机构：

[1] Univ Udine, S Maria Misericordia Univ Hosp, Dept Anesthesia & Intens Care Med, I-33100 Udine, Italy

来源：

MINERVA ANESTESIOLOGICA | 2009年 / 75卷 / 05期

关键词：

Neuromuscular blockade; Rocuronium; Anesthesia; ROCURONIUM; CYCLODEXTRINS; SUGAMMADEX; ANESTHESIA; TIME;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Postoperative residual curarization is still a problem of the modern anesthesia. Neostigmine is not the safest drug that allows a safe decurarization, especially when neuromuscular transmission monitoring is not used. Sugammadex is a A-cyclodextrin designed to encapsulate rocuronium bromide, providing a rapid reversal of neuromuscular blockade. It has not cardiovascular, respiratory, and cholinergic effects. It has been used in renally impaired patients with no neuromuscular blockade recurrence. Sugammadex reverses either a shallow or a deep neuromuscular block. Volatile agents Such as sevoflurane seems not to influence the sugammadex ability to reverse the rocuronium neuromuscular blockade. There is no difference in the sugammadex pharmacokinetic in children and adults. Sugammadex would be able to have a role in the future in reversing a non depolarizing steroidal neuromuscular block.

引用

页码：349 / 351

页数：3

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