Chronic fatigue and associated factors among long-term survivors of cancers in young adulthood

被引:37
作者
Bohn, Synne-Kristin H. [1 ]
Thorsen, Lene [1 ,2 ]
Kiserud, Cecilie E. [1 ]
Fossa, Sophie D. [1 ,3 ]
Li, Hanne C. [1 ,4 ]
Loge, Jon H. [4 ,5 ]
Wisloff, Torbjorn [6 ,7 ]
Haugnes, Hege S. [8 ,9 ]
Reinertsen, Kristin, V [1 ]
机构
[1] Oslo Univ Hosp, Dept Oncol, Natl Advisory Unit Late Effects Canc Treatment, Pb 4950 Nydalen, N-0424 Oslo, Norway
[2] Oslo Univ Hosp, Dept Clin Serv, Div Canc Med, Oslo, Norway
[3] Univ Oslo, Fac Med, Oslo, Norway
[4] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Behav Sci Med, Oslo, Norway
[5] Oslo Univ Hosp, Dept Oncol, Reg Advisory Unit Palliat Care, Oslo, Norway
[6] Norwegian Inst Publ Hlth, Dept Infect Dis Epidemiol & Modelling, Oslo, Norway
[7] Univ Oslo, Dept Hlth Management & Hlth Econ, Oslo, Norway
[8] Arctic Univ Tromso, Dept Clin Med, Tromso, Norway
[9] Univ Hosp North Norway, Dept Oncol, Tromso, Norway
基金
芬兰科学院;
关键词
QUALITY-OF-LIFE; HODGKIN-LYMPHOMA SURVIVORS; RISK-FACTORS; PREVALENCE; POPULATION; DEPRESSION; ADOLESCENTS; CHILDHOOD; OUTCOMES; ANXIETY;
D O I
10.1080/0284186X.2018.1557344
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Chronic fatigue (CF) is scarcely explored among young adult cancer survivors (YACSs), and more knowledge is needed to develop targeted interventions for YACSs with CF. The present study aimed to investigate the prevalence of CF and associated factors in YACSs. Also, the change of fatigue with time was explored.Material and methods: The present cross-sectional study is part of a nation-wide population based survey of Norwegian survivors of cancer in childhood, adolescence, and young adulthood (The NOR-CAYACS study).YACSs diagnosed at the age of 19-39 years with breast cancer stageIII (BC), colorectal cancer (CRC), non-Hodgkin lymphoma (NHL), acute lymphoblastic leukemia, or non-metastatic malignant melanoma (MM) were included 5-30 years after diagnosis. Survivors of MM treated with limited surgery were included as a reference group. CF was assessed by the Fatigue Questionnaire. Logistic regression analyses were performed to identify factors associated with CF.Results: In total, 1488 survivors completed the questionnaire (a response rate of 42%), of which 1088 were eligible for the present study. Overall, 25% reported CF. CF was significantly more prevalent among survivors of BC (29%) (p < .001), CRC (29%) (p = .001) and NHL (27%) (p = .003) than among survivors of MM (15%). CF was associated with systemic treatment combined with surgery and/or radiotherapy (p = .018), comorbidity (p = .038), pain (p = .002), numbness in hands/feet (p = .046), and depressive symptoms (p < .001) in the multivariable model. Among survivors with CF, 60% reported that they had been tired since cancer treatment, and among these, 65% reported worsening or no change of fatigue with time.Conclusion: One of four YACSs reported CF 15 years from diagnosis (mean). CF was associated with several possibly treatable factors. Health professionals involved in the follow-up of YACSs should have knowledge of CF and approaches to manage it.
引用
收藏
页码:753 / 762
页数:10
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