Radiation-induced second primary squamous cell carcinoma of the oral cavity after radiotherapy for nasopharyngeal carcinoma

被引:15
作者
Liu, Chao [1 ]
Liao, Lieqiang [2 ]
Wu, Guoying [3 ]
Yan, Honghong [4 ]
Chen, Xiaoqi [4 ]
Wang, Chao [4 ]
Zheng, Xiajing [4 ]
Zeng, Ziyi [5 ]
Zhao, Zheng [4 ]
Wu, Di [4 ]
Liu, Xuekui [4 ]
机构
[1] Jilin Univ, Sch Stomatol, Changchun 130041, Jilin, Peoples R China
[2] First Peoples Hosp Foshan, Dept Otolaryngol Head & Neck Surg, Foshan, Guangdong, Peoples R China
[3] Guangdong Prov Hosp Integrated Tradit Chinese & W, Wuhan, Peoples R China
[4] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Head & Neck Surg, State Key Lab Oncol South China,Canc Ctr, Guangzhou 510060, Peoples R China
[5] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol, State Key Lab Oncol South China,Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China
关键词
Radiation-induced; Second primary squamous cell carcinoma; Oral cavity; Nasopharyngeal carcinoma; Prognosis; PRIMARY MALIGNANCIES; INDUCED SARCOMA; RISK; CANCERS; TONGUE; IMPACT; TUMORS;
D O I
10.1016/j.oraloncology.2020.104863
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The increasing occurrence of radiation-induced second primary squamous cell carcinoma of the oral cavity (RISCCO) after radiotherapy for nasopharyngeal carcinoma (NPC) has become a noteworthy complication that can influence long-term survival. This study aimed to analyze the associations of clinicopathologic characteristics with prognostic factors among patients who developed RISCCO after radiotherapy for NPC. Methods: A total of 41,446 NPC patients admitted to Sun Yat-sen University Cancer Center (SYSUCC) between August 1989 and January 2019 were reviewed. Among these patients, 88 RISCCO patients who satisfied the inclusion criteria were included in the study. Results: During our study, the incidence of RISCCO after radiotherapy was 0.21% (88/41,446) among NPC patients at SYSUCC. The latency period ranged from 1.0 to 34.0 years (median, 9.0 years), and the latency of RISCCO was notably shorter for patients who received intensity-modulated radiation therapy than that for patients who received conventional radiotherapy using cobalt-60 or 6-MV X-rays (median, 4.0 years vs. 11.0 years, P = 0.013). The 1-, 3-, and 5-year overall survival (OS) rates for the entire cohort of 88 patients were 79.0%, 46.6%, and 35.2%, respectively. The 5-year OS rate for the 79 patients who received treatment was 45.7%, and the 5-year OS rate for the 9 patients who refused treatment was 0%. T classification and surgery were identified as independent prognostic factors associated with a high OS rate. Conclusions: Surgery as the first-choice treatment may improve survival and prognosis. A long-term follow-up is needed for early detection of RISCCO in NPC patients.
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页数:6
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