A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters

被引：7

作者：

Kostaki, Evangelia Georgia ^{[1
]}

Gova, Maria ^{[1
]}

Adamis, Georgios ^{[2
]}

Xylomenos, Georgios ^{[2
]}

Chini, Maria ^{[3
]}

Mangafas, Nikos ^{[3
]}

Lazanas, Marios ^{[3
]}

Metallidis, Simeon ^{[4
]}

Tsachouridou, Olga ^{[4
]}

Papastamopoulos, Vasileios ^{[5
]}

Chatzidimitriou, Dimitrios ^{[6
]}

Kakalou, Eleni ^{[5
]}

Antoniadou, Anastasia ^{[7
]}

Papadopoulos, Antonios ^{[7
]}

Psichogiou, Mina ^{[8
]}

Basoulis, Dimitrios ^{[8
]}

Pilalas, Dimitrios ^{[6
]}

Papageorgiou, Ifigeneia ^{[1
]}

Paraskeva, Dimitra ^{[9
]}

Chrysos, Georgios ^{[9
]}

Paparizos, Vasileios ^{[10
]}

Kourkounti, Sofia ^{[10
]}

Sambatakou, Helen ^{[11
]}

Bolanos, Vasileios ^{[11
]}

Sipsas, Nikolaos V. ^{[12
]}

Lada, Malvina ^{[13
]}

Barbounakis, Emmanouil ^{[14
]}

Kantzilaki, Evrikleia ^{[14
]}

Panagopoulos, Periklis ^{[15
]}

Petrakis, Vasilis ^{[15
]}

Drimis, Stelios ^{[9
]}

Gogos, Charalambos ^{[16
]}

Hatzakis, Angelos ^{[1
]}

Beloukas, Apostolos ^{[17
,18
]}

Skoura, Lemonia ^{[6
]}

Paraskevis, Dimitrios ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, Athens 11527, Greece

[2] G Gennimatas Gen Hosp, Dept Internal Med 1, Athens 11527, Greece

[3] Korgialeneio Benakeio Red Cross Gen Hosp, Dept Internal Med 3, Infect Dis Unit, Athens 11526, Greece

[4] Aristotle Univ Thessaloniki, Ahepa Univ Hosp, Med Sch, Dept Internal Med 1, Thessaloniki 54636, Greece

[5] Evaggelismos Gen Hosp, Dept Internal Med & Infect Dis 5, Athens 10676, Greece

[6] Aristotle Univ Thessaloniki, Med Sch, Dept Microbiol, Natl AIDS Reference Ctr Northern Greece, Thessaloniki 54124, Greece

[7] Natl & Kapodistrian Univ Athens, Med Sch, Attikon Gen Hosp, Dept Med 4, Athens 12462, Greece

[8] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Med Sch, Dept Med 1, Athens 11527, Greece

[9] Tzaneio Gen Hosp, Dept Internal Med, Piraeus 18536, Greece

[10] A Syngros Hosp Dermatol & Venereol, HIV AIDS Unit, Athens 16121, Greece

[11] Natl & Kapodistrian Univ Athens, Hippokrat Gen Hosp, Med Sch, HIV Unit,Dept Internal Med 2, Athens 11527, Greece

[12] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Med Sch, Dept Pathophysiol, Athens 11527, Greece

[13] Sismanogle Gen Hosp, Dept Internal Med 2, Maroussi 15126, Greece

[14] Univ Crete, Univ Hosp Herakl PAGNI, Med Sch, Dept Internal Med, Iraklion 71110, Greece

[15] Democritus Univ Thrace, Univ Gen Hosp, Dept Internal Med, Alexandroupolis 68100, Greece

[16] Univ Hosp Patras, Dept Internal Med & Infect Dis, Rion 26504, Greece

[17] Univ Liverpool, Inst Infect & Global Hlth, Dept Clin Infect Microbiol & Immunol, Liverpool L697BE, Merseyside, England

[18] Univ West Attica, Sch Hlth Sci, Dept Biomed Sci, Athens 12243, Greece

来源：

VIRUSES-BASEL | 2020年 / 12卷 / 10期

关键词：

human immunodeficiency virus (HIV); molecular epidemiology; phylogenetic analysis; phylogeographic analysis; local transmission; dispersal patterns; transmission clusters; Greece; TRANSMITTED DRUG-RESISTANCE; PHYLOGENETIC ANALYSIS; EPIDEMIOLOGY; INFECTION; NETWORKS; INSIGHTS; PREVALENCE; ORIGIN; SPREAD; USERS;

D O I：

10.3390/v12101183

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Our aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.8%) sequences of subtype A1 and B, respectively. Identification of MTCs was based on phylogenetic analysis. The analyses identified 38 MTCs including 2-1518 subtype A1 sequences and 168 MTCs in the range of 2-218 subtype B sequences. The proportion of sequences within MTCs was 93.8% (1642/1751) and 77.0% (1982/2575) for subtype A1 and B, respectively. Transmissions within MTCs for subtype A1 were associated with risk group (Men having Sex with Men vs. heterosexuals, OR = 5.34, p < 0.001) and Greek origin (Greek vs. non-Greek origin, OR = 6.05, p < 0.001) and for subtype B, they were associated with Greek origin (Greek vs. non-Greek origin, OR = 1.57, p = 0.019), younger age (OR = 0.96, p < 0.001), and more recent sampling (time period: 2011-2015 vs. 1999-2005, OR = 3.83, p < 0.001). Our findings about the patterns of across and within country dispersal as well as the parameters associated with transmission within MTCs provide a framework for the application of the study of molecular clusters for HIV prevention.

引用

页数：16

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