Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

被引:70
|
作者
Rahman, Heshu Sulaiman [1 ,2 ,3 ]
Rasedee, Abdullah [1 ,2 ]
Yeap, Swee Keong [2 ]
Othman, Hemn Hassan [1 ,3 ]
Chartrand, Max Stanley [4 ]
Namvar, Farideh [5 ]
Abdul, Ahmad Bustamam [2 ]
How, Chee Wun [2 ]
机构
[1] Univ Putra Malaysia, Fac Vet Med, Dept Vet Clin Diag, Serdang 43400, Selangor, Malaysia
[2] Univ Putra Malaysia, Inst Biosci, Serdang 43400, Selangor, Malaysia
[3] Univ Sulaimanyah, Fac Vet Med, Dept Microbiol, Sulaymaniyah, Kurdistan Regio, Iraq
[4] DigiCare Behav Res, Casa Grande, AZ USA
[5] Univ Putra Malaysia, Inst Trop Forestry & Forest Prod INTROP, Serdang 43400, Selangor, Malaysia
关键词
CELL-CYCLE ARREST; NF-KAPPA-B; TROPICAL GINGER SESQUITERPENE; FREE-RADICAL GENERATION; ZINGIBER-ZERUMBET; SUBTROPICAL GINGER; APOPTOSIS; EXPRESSION; EXTRACT; RHIZOMES;
D O I
10.1155/2014/920742
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER.
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页数:20
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