Mass spectrometry of natural products: current, emerging and future technologies

被引:151
作者
Bouslimani, Amina [2 ]
Sanchez, Laura M. [2 ]
Garg, Neha [2 ]
Dorrestein, Pieter C. [1 ,2 ]
机构
[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
DESORPTION ELECTROSPRAY-IONIZATION; FUNGAL SECONDARY METABOLITES; HIGH-RESOLUTION; STREPTOMYCES-COELICOLOR; AMBIENT CONDITIONS; ION-TRAP; NONRIBOSOMAL PEPTIDES; MOLECULAR NETWORKING; FRAGMENTATION TREES; BACILLUS-SUBTILIS;
D O I
10.1039/c4np00044g
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although mass spectrometry is a century old technology, we are entering into an exciting time for the analysis of molecular information directly from complex biological systems. In this Highlight, we feature emerging mass spectrometric methods and tools used by the natural product community and give a perspective of future directions where the mass spectrometry field is migrating towards over the next decade.
引用
收藏
页码:718 / 729
页数:12
相关论文
共 111 条
  • [21] Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging
    Esquenazi, Eduardo
    Coates, Cameron
    Simmons, Luke
    Gonzalez, David
    Gerwick, William H.
    Dorrestein, Pieter C.
    [J]. MOLECULAR BIOSYSTEMS, 2008, 4 (06) : 562 - 570
  • [22] Ion mobility mass spectrometry enables the efficient detection and identification of halogenated natural products from cyanobacteria with minimal sample preparation
    Esquenazi, Eduardo
    Daly, Michael
    Bahrainwala, Tasneem
    Gerwick, William H.
    Dorrestein, Pieter C.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (22) : 6639 - 6644
  • [23] Imaging mass spectrometry of natural products
    Esquenazi, Eduardo
    Yang, Yu-Liang
    Watrous, Jeramie
    Gerwick, William H.
    Dorrestein, Pieter C.
    [J]. NATURAL PRODUCT REPORTS, 2009, 26 (12) : 1521 - 1534
  • [24] Probing marine natural product defenses with DESI-imaging mass spectrometry
    Esquenazi, Eduardo
    Dorrestein, Pieter C.
    Gerwick, William H.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (18) : 7269 - 7270
  • [25] ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES
    FENN, JB
    MANN, M
    MENG, CK
    WONG, SF
    WHITEHOUSE, CM
    [J]. SCIENCE, 1989, 246 (4926) : 64 - 71
  • [26] Miniaturization and geometry optimization of a polymer-based rectilinear ion trap
    Fico, Miriam
    Yu, Meng
    Ouyang, Zheng
    Cooks, R. Graham
    Chappell, William J.
    [J]. ANALYTICAL CHEMISTRY, 2007, 79 (21) : 8076 - 8082
  • [27] Circular arrays of polymer-based miniature rectilinear ion traps
    Fico, Miriam
    Maas, Jeffrey D.
    Smith, Scott A.
    Costa, Anthony B.
    Ouyang, Zheng
    Chappell, William J.
    Cooks, R. Graham
    [J]. ANALYST, 2009, 134 (07) : 1338 - 1347
  • [28] NMR-spectroscopic analysis of mixtures: from structure to function
    Forseth, Ry R.
    Schroeder, Frank C.
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2011, 15 (01) : 38 - 47
  • [29] Axial CID and High Pressure Resonance CID in a Miniature Ion Trap Mass Spectrometer Using a Discontinuous Atmospheric Pressure Interface
    Gao, Liang
    Li, Guangtao
    Cooks, R. Graham
    [J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2010, 21 (02) : 209 - 214
  • [30] Distribution and Possible Function of the Marine Alkaloid, Norzoanthamine, in the Zoanthid Zoanthus sp Using MALDI Imaging Mass Spectrometry
    Genji, Takahisa
    Fukuzawa, Seketsu
    Tachibana, Kazuo
    [J]. MARINE BIOTECHNOLOGY, 2010, 12 (01) : 81 - 87