Achillea biebersteinni Afan may inhibit scar formation: In vitro study

被引:15
作者
Hormozi, Maryam [1 ,2 ]
Baharvand, Parastoo [3 ]
机构
[1] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran
[2] Lorestan Univ Med Sci, Dept Biochem, Khorramabad, Iran
[3] Lorestan Univ Med Sci, Dept Community Med, Khorramabad, Iran
关键词
Achillea biebersteinni Afan; bFGF; fibroblast; scar formation; TGF beta 1; FIBROBLAST-GROWTH-FACTOR; ANTIMICROBIAL ACTIVITY; EXPRESSION; MIGRATION; EXTRACT; BFGF; L;
D O I
10.1002/mgg3.640
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
BackgroundOne of the major problems in wound healing is scar formation; however, there are few ways to prevent or treat it. Different species of Achillea are used to treat wounds in folk medicine from the past but there are few studies on the effect of it on wound healing and inhibition of scar formation. The aim of this study was to investigate the effect of Achillea biebersteinii Afan hydroethanolic extract on the expression of TGF1 and bFGF as effective growth factors of wound healing in mouse embryonic fibroblast cells. MethodsMouse embryonic fibroblast cells were exposed to different concentrations of Achillea extract at two different time (12 and 24hr); the expression of TGF1 and bFGF was performed by real-time-PCR and ELISA at the level of gene and protein. ResultsIt was observed that the plant extract at 5 and 10 mu g/ml downregulated the expression of TGF1 and upregulated the expression of bFGF at the level of gene and protein. ConclusionThe results showed that the pattern of changes in the expression of TGF1 and bFGF by Achillea biebersteinni Afan extract may inhibit scar formation.
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页数:8
相关论文
共 36 条
[1]  
Akita S., 2010, COLOR ATLAS BURN REC, P62
[2]   Basic Fibroblast Growth Factor in Scarless Wound Healingyy [J].
Akita, Sadanori ;
Akino, Kozo ;
Hirano, Akiyoshi .
ADVANCES IN WOUND CARE, 2013, 2 (02) :44-49
[3]   Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models [J].
Akkol, Esra Kupeli ;
Koca, Ufuk ;
Pesin, Ipek ;
Yilmazer, Demet .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 2011
[4]   Pharmacognosy, Phytochemistry and Pharmacological Properties of Achillea millefolium L.: A Review [J].
Ali, Sofi Imtiyaz ;
Gopalakrishnan, B. ;
Venkatesalu, V. .
PHYTOTHERAPY RESEARCH, 2017, 31 (08) :1140-1161
[5]  
[Anonymous], 2000, HERBAL MED EXPANDED
[6]  
Brown JE, 1998, BIOCHEM J, V330, P1173
[7]   Achillea asiatica extract and its active compounds induce cutaneous wound healing [J].
Dorjsembe, Banzragch ;
Lee, Hee Ju ;
Kim, Myungsuk ;
Dulamjav, Batsuren ;
Jigjid, Tunsag ;
Nho, Chu Won .
JOURNAL OF ETHNOPHARMACOLOGY, 2017, 206 :306-314
[8]  
Ghobadian Zahra, 2015, Med Arch, V69, P212, DOI 10.5455/medarh.2015.69.212-217
[9]   Wound healing: The role of growth factors [J].
Grazul-Bilska, AT ;
Johnson, ML ;
Bilski, JJ ;
Redmer, DA ;
Reynolds, LP ;
Abdullah, A ;
Abdullah, KM .
DRUGS OF TODAY, 2003, 39 (10) :787-800
[10]   The effect of aloe vera on the expression of wound healing factors (TGFβ1 and bFGF) in mouse embryonic fibroblast cell: In vitro study [J].
Hormozi, Maryam ;
Assaei, Raheleh ;
Boroujeni, Mandana Beigi .
BIOMEDICINE & PHARMACOTHERAPY, 2017, 88 :610-616