Interleukin 10 Receptor Signaling: Master Regulator of Intestinal Mucosal Homeostasis in Mice and Humans

被引：242

作者：

Shouval, Dror S. ^{[1
]}

Ouahed, Jodie ^{[1
]}

Biswas, Amlan ^{[1
]}

Goettel, Jeremy A. ^{[1
]}

Horwitz, Bruce H. ^{[5
]}

Klein, Christoph ^{[6
]}

Muise, Aleixo M. ^{[2
,3
]}

Snapper, Scott B. ^{[1
,4
]}

机构：

[1] Harvard Univ, Sch Med, Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Boston, MA 02130 USA

[2] Hosp Sick Children, Dept Paediat, Div Gastroenterol Hepatol & Nutr, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Cell Biol Program, Toronto, ON, Canada

[4] Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA

[5] Boston Childrens Hosp, Div Emergency Med, Boston, MA USA

[6] Univ Munich, Dr von Hauner Childrens Hosp, Munich, Germany

来源：

ADVANCES IN IMMUNOLOGY, VOL 122 | 2014年 / 122卷

关键词：

INFLAMMATORY-BOWEL-DISEASE; RECOMBINANT HUMAN INTERLEUKIN-10; ACTIVATED PROTEIN-KINASE; ANTIGEN-PRESENTING CELL; CD4(+) T-CELLS; DENDRITIC CELLS; CROHNS-DISEASE; ULCERATIVE-COLITIS; CUTTING EDGE; HELICOBACTER-HEPATICUS;

D O I：

10.1016/B978-0-12-800267-4.00005-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. Here, we review recent findings on how IL10- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine gastrointestinal tract, with implications of their role in the prevention of inflammatory bowel disease (IBD). In addition, we discuss the impact of IL10 and IL10R signaling defects in humans and their relationship to very early-onset IBD (VEO-IBD).

引用

页码：177 / 210

页数：34

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